Recent Advances of L-ornithine Biosynthesis in Metabolically Engineered Corynebacterium glutamicum

被引：0
|
作者：
Wu, Xiao-Yu [1 ]
Guo, Xiao-Yan [1 ]
Zhang, Bin [1 ]
Jiang, Yan [1 ]
Ye, Bang-Ce [2 ]
机构：
[1] Jiangxi Engineering Laboratory for the Development and Utilization of Agricultural Microbial Resources, College of Bioscience and Engineering, Jiangxi Agricultural University, Nanchang, China
[2] Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China
来源：
Frontiers in Bioengineering and Biotechnology | 2020年 / 7卷
关键词：
L-ornithine; a valuable non-protein amino acid; has a wide range of applications in the pharmaceutical and food industries. Currently; microbial fermentation is a promising; sustainable; and environment-friendly method to produce L-ornithine. However; the industrial production capacity of L-ornithine by microbial fermentation is low and rarely meets the market demands. Various strategies have been employed to improve the L-ornithine production titers in the model strain; Corynebacterium glutamicum; which serves as a major indicator for improving the cost-effectiveness of L-ornithine production by microbial fermentation. This review focuses on the development of high L-ornithine-producing strains by metabolic engineering and reviews the recent advances in breeding strategies; such as reducing by-product formation; improving the supplementation of precursor glutamate; releasing negative regulation and negative feedback inhibition; increasing the supply of intracellular cofactors; modulating the central metabolic pathway; enhancing the transport system; and adaptive evolution for improving L-ornithine production. © Copyright © 2020 Wu; Guo; Zhang; Jiang and Ye;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Production of l-valine from metabolically engineered Corynebacterium glutamicum
    Xiaoyuan Wang
    Hailing Zhang
    Peter J. Quinn
    Applied Microbiology and Biotechnology, 2018, 102 : 4319 - 4330
  • [22] Metabolic engineering of Corynebacterium glutamicum for increasing the production of L-ornithine by increasing NADPH availability
    Jiang, Ling-Yan
    Zhang, Yuan-Yuan
    Li, Zhen
    Liu, Jian-Zhong
    JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2013, 40 (10) : 1143 - 1151
  • [23] Biosynthesis of Chondroitin in Engineered Corynebacterium glutamicum
    Cheng, Fangyu
    Luozhong, Sijin
    Yu, Huimin
    Guo, Zhigang
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 29 (03) : 392 - 400
  • [24] Increased L-Ornithine Production in Corynebacterium glutamicum by Overexpression of a Gene Encoding a Putative Aminotransferase
    Kim, Dai-Joong
    Hwang, Gui-Hye
    Um, Ji-Na
    Cho, Jae-Yong
    JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, 2015, 25 (01) : 45 - 50
  • [25] Systematic pathway engineering of Corynebacterium glutamicum S9114 for l-ornithine production
    Zhang, Bin
    Yu, Miao
    Zhou, Ying
    Li, Yixue
    Ye, Bang-Ce
    MICROBIAL CELL FACTORIES, 2017, 16
  • [26] Biosynthesis of L-histidine from marine biomass-derived galactans in metabolically engineered Corynebacterium glutamicum
    Kim, Minhye
    Oh, Jun Won
    Jeong, Da Woon
    Cho, Byeong-Hyeon
    Chang, Joonhee
    Shi, Xiaoyu
    Han, Sung Ok
    BIORESOURCE TECHNOLOGY, 2024, 391
  • [27] Systematic pathway engineering of Corynebacterium glutamicum S9114 for l-ornithine production
    Bin Zhang
    Miao Yu
    Ying Zhou
    Yixue Li
    Bang-Ce Ye
    Microbial Cell Factories, 16
  • [28] Fermentative aminopyrrolnitrin production by metabolically engineered Corynebacterium glutamicum
    Putri, Virginia Ryandini Melati
    Jung, Min-Hee
    Lee, Ji-Young
    Kwak, Mi-Hyang
    Mariyes, Theavita Chatarina
    Kerbs, Anastasia
    Wendisch, Volker F.
    Kong, Hee Jeong
    Kim, Young-Ok
    Lee, Jin-Ho
    MICROBIAL CELL FACTORIES, 2024, 23 (01)
  • [29] Production of the sesquiterpene (+)-valencene by metabolically engineered Corynebacterium glutamicum
    Frohwitter, Jonas
    Heider, Sabine A. E.
    Peters-Wendisch, Petra
    Beekwilder, Jules
    Wendisch, Volker F.
    JOURNAL OF BIOTECHNOLOGY, 2014, 191 : 205 - 213
  • [30] Engineering of Corynebacterium glutamicum to Enhance L-ornithine Production by Gene Knockout and Comparative Proteomic Analysis
    Lu Dongmei
    Liu Jianzhong
    Mao Zongwan
    CHINESE JOURNAL OF CHEMICAL ENGINEERING, 2012, 20 (04) : 731 - 739
12345