Recent Advances of L-ornithine Biosynthesis in Metabolically Engineered Corynebacterium glutamicum

被引：0
|
作者：
Wu, Xiao-Yu [1 ]
Guo, Xiao-Yan [1 ]
Zhang, Bin [1 ]
Jiang, Yan [1 ]
Ye, Bang-Ce [2 ]
机构：
[1] Jiangxi Engineering Laboratory for the Development and Utilization of Agricultural Microbial Resources, College of Bioscience and Engineering, Jiangxi Agricultural University, Nanchang, China
[2] Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China
来源：
Frontiers in Bioengineering and Biotechnology | 2020年 / 7卷
关键词：
L-ornithine; a valuable non-protein amino acid; has a wide range of applications in the pharmaceutical and food industries. Currently; microbial fermentation is a promising; sustainable; and environment-friendly method to produce L-ornithine. However; the industrial production capacity of L-ornithine by microbial fermentation is low and rarely meets the market demands. Various strategies have been employed to improve the L-ornithine production titers in the model strain; Corynebacterium glutamicum; which serves as a major indicator for improving the cost-effectiveness of L-ornithine production by microbial fermentation. This review focuses on the development of high L-ornithine-producing strains by metabolic engineering and reviews the recent advances in breeding strategies; such as reducing by-product formation; improving the supplementation of precursor glutamate; releasing negative regulation and negative feedback inhibition; increasing the supply of intracellular cofactors; modulating the central metabolic pathway; enhancing the transport system; and adaptive evolution for improving L-ornithine production. © Copyright © 2020 Wu; Guo; Zhang; Jiang and Ye;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Enhancement of L-ornithine production by disruption of three genes encoding putative oxidoreductases in Corynebacterium glutamicum
    Hwang, Gui-Hye
    Cho, Jae-Yong
    JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2014, 41 (03) : 573 - 578
  • [32] Biosynthesis of Apigenin Glucosides in Engineered Corynebacterium glutamicum
    Amoah, Obed Jackson
    Thapa, Samir Bahadur
    Ma, Su Yeong
    Nguyen, Hue Thi
    Zakaria, Morshed Md
    Sohng, Jae Kyung
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2024, 34 (05) : 1154 - 1163
  • [33] Engineering of Corynebacterium glutamicum for growth and production of L-ornithine, L-lysine, and lycopene from hexuronic acids
    Atika Hadiati
    Irene Krahn
    Steffen N Lindner
    Volker F Wendisch
    Bioresources and Bioprocessing, 1 (1)
  • [34] Production of the Marine Carotenoid Astaxanthin by Metabolically Engineered Corynebacterium glutamicum
    Henke, Nadja A.
    Heider, Sabine A. E.
    Peters-Wendisch, Petra
    Wendisch, Volker F.
    MARINE DRUGS, 2016, 14 (07):
  • [35] Engineering of corynebacterium glutamicum for growth and production of L-ornithine, L-lysine, and lycopene from hexuronic acids
    Wendisch, Volker F. (volker.wendisch@uni-bielefeld.de), 1600, Springer Science and Business Media Deutschland GmbH (01):
  • [36] Ecofriendly Synthesis of L-Carnosine in Metabolically Engineered Corynebacterium glutamicum by Reinforcing Precursor Accumulation
    Kim, Minhye
    Ko, Young Jin
    Jeong, Da Woon
    Jeong, Wu-Young
    Han, Sung Ok
    ACS SYNTHETIC BIOLOGY, 2021, 10 (06): : 1553 - 1562
  • [37] Transcriptomic Changes in Response to Putrescine Production in Metabolically Engineered Corynebacterium glutamicum
    Li, Zhen
    Liu, Jian-Zhong
    FRONTIERS IN MICROBIOLOGY, 2017, 8
  • [38] Microbial synthesis of sedoheptulose from glucose by metabolically engineered Corynebacterium glutamicum
    Liu, Yinlu
    Dong, Qianzhen
    Song, Wan
    Pei, Wenwen
    Zeng, Yan
    Wang, Min
    Sun, Yuanxia
    Ma, Yanhe
    Yang, Jiangang
    MICROBIAL CELL FACTORIES, 2024, 23 (01)
  • [39] Improvement in l-ornithine production from mannitol via transcriptome-guided genetic engineering in Corynebacterium glutamicum
    Libin Nie
    Yutong He
    Lirong Hu
    Xiangdong Zhu
    Xiaoyu Wu
    Bin Zhang
    Biotechnology for Biofuels and Bioproducts, 15
  • [40] Aerobic production of succinate from arabinose by metabolically engineered Corynebacterium glutamicum
    Chen, Tao
    Zhu, Nianqing
    Xia, Huihua
    BIORESOURCE TECHNOLOGY, 2014, 151 : 411 - 414
12345