Recent Advances of L-ornithine Biosynthesis in Metabolically Engineered Corynebacterium glutamicum

被引：0

作者：

Wu, Xiao-Yu ^{[1
]}

Guo, Xiao-Yan ^{[1
]}

Zhang, Bin ^{[1
]}

Jiang, Yan ^{[1
]}

Ye, Bang-Ce ^{[2
]}

机构：

[1] Jiangxi Engineering Laboratory for the Development and Utilization of Agricultural Microbial Resources, College of Bioscience and Engineering, Jiangxi Agricultural University, Nanchang, China

[2] Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China

来源：

Frontiers in Bioengineering and Biotechnology | 2020年 / 7卷

关键词：

L-ornithine; a valuable non-protein amino acid; has a wide range of applications in the pharmaceutical and food industries. Currently; microbial fermentation is a promising; sustainable; and environment-friendly method to produce L-ornithine. However; the industrial production capacity of L-ornithine by microbial fermentation is low and rarely meets the market demands. Various strategies have been employed to improve the L-ornithine production titers in the model strain; Corynebacterium glutamicum; which serves as a major indicator for improving the cost-effectiveness of L-ornithine production by microbial fermentation. This review focuses on the development of high L-ornithine-producing strains by metabolic engineering and reviews the recent advances in breeding strategies; such as reducing by-product formation; improving the supplementation of precursor glutamate; releasing negative regulation and negative feedback inhibition; increasing the supply of intracellular cofactors; modulating the central metabolic pathway; enhancing the transport system; and adaptive evolution for improving L-ornithine production. © Copyright © 2020 Wu; Guo; Zhang; Jiang and Ye;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 50 条

[1] Recent Advances of L-ornithine Biosynthesis in Metabolically Engineered Corynebacterium glutamicum
Wu, Xiao-Yu
Guo, Xiao-Yan
Zhang, Bin
Jiang, Yan
Ye, Bang-Ce
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 7
[2] Recent Advances in L-Methionine Biosynthesis in Metabolically Engineered Corynebacterium glutamicum and Escherichia coli
Liu Y.
Jiang Z.
Gao X.
Zeng Q.
Wang Y.
Liu X.
Min W.
Shipin Kexue/Food Science, 2023, 44 (13): : 226 - 234
[3] Implication of gluconate kinase activity in L-ornithine biosynthesis in Corynebacterium glutamicum
Hwang, Gui-Hye
Cho, Jae-Yong
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2012, 39 (12) : 1869 - 1874
[4] Enhanced L-ornithine production by systematic manipulation of L-ornithine metabolism in engineered Corynebacterium glutamicum S9114
Zhang, Bin
Ren, Li-Quan
Yu, Miao
Zhou, Ying
Ye, Bang-Ce
BIORESOURCE TECHNOLOGY, 2018, 250 : 60 - 68
[5] Metabolic Engineering of Corynebacterium glutamicum for the Production of L-Ornithine
Kim, Seo Yun
Lee, Joungmin
Lee, Sang Yup
BIOTECHNOLOGY AND BIOENGINEERING, 2015, 112 (02) : 416 - 421
[6] Implication of ornithine acetyltransferase activity on L-ornithine production in Corynebacterium glutamicum
Hao, Ning
Mu, Jingrui
Hu, Nan
Xu, Sheng
Shen, Peng
Yan, Ming
Li, Yan
Xu, Lin
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2016, 63 (01) : 15 - 21
[7] Highly efficient biosynthesis of L-ornithine from mannitol by using recombinant Corynebacterium glutamicum
Sheng, Qi
Wu, Xiaoyu
Jiang, Yan
Li, Zhimin
Wang, Fei
Zhang, Bin
BIORESOURCE TECHNOLOGY, 2021, 327
[8] Improvement of l-ornithine production by attenuation of argF in engineered Corynebacterium glutamicum S9114
Bin Zhang
Miao Yu
Ying Zhou
Bang-Ce Ye
AMB Express, 8
[9] Improvement of L-ornithine production by attenuation of argF in engineered Corynebacterium glutamicum S9114
Zhang, Bin
Yu, Miao
Zhou, Ying
Ye, Bang-Ce
AMB EXPRESS, 2018, 8
[10] Metabolic evolution of Corynebacterium glutamicum for increased production of L-ornithine
Ling-Yan Jiang
Shang-Guang Chen
Yuan-Yuan Zhang
Jian-Zhong Liu
BMC Biotechnology, 13

← 1 2 3 4 5 →