Observing shear flow induced conformational changes of vWF using TEM

被引：0
|
作者：
Xu, Yangqing [1 ]
Bao, Gang [1 ]
机构：
[1] Biomedical Engineering Soc, Atlanta, United States
来源：
Annals of Biomedical Engineering | 2000年 / 28卷 / SUPPL. 1期
关键词：
Cells - Conformations - Molecules - Proteins - Transmission electron microscopy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A transmission electron microscopy (TEM) study of vWF conformational change was carried out. TEM images were taken to compare the conformations before and after shear flow was applied. The vWF multimers initially coiled and become extended. The degree of conformational changes increased with the applied shear rate.
引用
收藏
相关论文
共 50 条
  • [31] LARGE VWF MULTIMERS ARE INVOLVED IN SHEAR STRESS-INDUCED PLATELET-AGGREGATION
    MOAKE, JL
    STATHOPOULOS, NA
    HELLUMS, JD
    TURNER, NA
    NOLASCO, LH
    CIRCULATION, 1986, 74 (04) : 63 - 63
  • [32] Shear-Induced Unfolding and Enzymatic Cleavage of Full-Length VWF Multimers
    Lippok, Svenja
    Radtke, Matthias
    Obser, Tobias
    Kleemeier, Lars
    Schneppenheim, Reinhard
    Budde, Ulrich
    Netz, Roland R.
    Raedler, Joachim O.
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 545 - 554
  • [33] Charge-induced conformational changes of dendrimers
    Blaak, Ronald
    Lehmann, Swen
    Likos, Christos N.
    MACROMOLECULES, 2008, 41 (12) : 4452 - 4458
  • [34] INDUCED CONFORMATIONAL-CHANGES IN ENZYME CONTROL
    KOSHLAND, DE
    SEIKAGAKU, 1973, 45 (11): : 941 - 950
  • [35] PH-INDUCED CONFORMATIONAL CHANGES OF DNA
    COSTANTI.L
    VITAGLIA.V
    BIOPOLYMERS, 1966, 4 (05) : 521 - &
  • [36] CONFORMATIONAL-CHANGES IN RIBOSOMES INDUCED BY ALCOHOLS
    BERNABEU, C
    VAZQUEZ, D
    BALLESTA, JPG
    FEBS LETTERS, 1979, 99 (02) : 251 - 254
  • [37] Investigation of induced conformational changes in dihydrofolate reductase
    Cornillie, Sean
    Cheatham, Thomas
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [38] Substrate induced conformational changes in argininosuccinate synthetase
    Lemke, CT
    Howell, PL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (15) : 13074 - 13081
  • [39] UV INDUCED CONFORMATIONAL CHANGES IN TRANSFER RNA
    SARIN, PS
    JOHNS, HE
    PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1968, 7 (02) : 203 - &
  • [40] LIGAND-INDUCED CONFORMATIONAL CHANGES IN RIBONUCLEASE
    MARKUS, G
    BARNARD, EA
    CASTELLANI, BA
    SAUNDERS, D
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1968, 243 (15) : 4070 - +
12345