Trifluoromethyl-substituted pyridines through displacement of iodine by in situ generated (trifluoromethyl)copper

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作者
Cottet, Fabrice [1 ]
Schlosser, Manfred [1 ]
机构
[1] Section de Chimie (BCh), Universite, 1015 Lausanne, Switzerland
关键词
Copper; -; Iodine; Nitrogen; Pyridine;
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摘要
A literature method reported for iodobenzene and congeners was successfully extended to the pyridine series. 2-Iodopyridines can be converted into 2-(trifluoromethyl)pyridines almost quantitatively. In contrast, yields ore moderate at best if 3- and 4-iodopyridines or 2-bromopyridines are used as the starting materials.
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页码:327 / 330
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