Development of a Stereospecific Strategy for the Total Synthesis of Diplodialide C and Formal Synthesis of (-)-Curvularin

被引：0

作者：

Kumar, Ravan ^{[1
]}

Banerjee, Amit ^{[1
]}

Saha, Sumit ^{[1
]}

机构：

[1] Natl Inst Technol Sikkim, Dept Chem, Ravangla 737139, India

来源：

SYNLETT | 2025年 / 36卷 / 06期

关键词：

total synthesis; natural products; pentaketides; macrolide; epoxides; Shiina macrolactonization; STEREOSELECTIVE-SYNTHESIS;

D O I：

10.1055/s-0043-1775057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise and efficient stereospecific approach for the total synthesis of diplodialide C (R, R and S, S isomers) has been demonstrated using chiral homoglycidol and propylene oxide as a source of starting material. Further oxidized ketolide product derived from diplodialide C (S, S isomer) was applied to the formal synthesis of (-)-curvularin following reported known literature.

引用

页码：679 / 682

页数：4

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