First Total Synthesis of Gliomasolide C and Formal Total Synthesis of Sch-725674

被引：18

作者：

Seetharamsingh, B. ^{[1
]}

Khairnar, Pankaj V. ^{[1
]}

Reddy, D. Srinivasa ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, CSIR, Pune 411008, Maharashtra, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 01期

关键词：

OLEFIN METATHESIS CATALYSTS; ASYMMETRIC DIHYDROXYLATION; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; CROSS-METATHESIS; MACROLIDE; OXIDATION; FUNGUS; CELL; SEKOTHRIXIDE;

D O I：

10.1021/acs.joc.5b02318

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of two 14-membered macrolides Sch-725674 and Gliomasolide C are described here. The first total synthesis of Gliomasolide C, the short synthesis of Sch-725674, and regios elective Wacker oxidation of internal olefin are the highlights of this disclosure. In addition, a key macrocyde with orthogonal functionalities was designed and synthesized on a gram scale for the generation of analogues.

引用

页码：290 / 296

页数：7

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