Enantiospecific Total Synthesis of Macrolactone Sch 725674

被引：24
|
作者：
Bali, Amit K. [1 ]
Sunnam, Sunil K. [1 ]
Prasad, Kavirayani R. [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 15期
关键词：
RING-CLOSING METATHESIS; SCH725674; DITHIOLS; STRATEGY;
D O I：
10.1021/ol5018678
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The enantiospecific total synthesis of 14-membered macrolactone Sch 725674 was accomplished from tartaric acid. Key reactions in the synthesis include the Ley's dithiaketalization of an alkynone derived from the bis-Weinreb amide of tartaric acid, Boord olefination, and ring-closing metathesis of an acrylate ester.
引用
收藏
页码：4001 / 4003
页数：3
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