Enantiospecific Total Synthesis of Macrolactone Sch 725674

被引：24

作者：

Bali, Amit K. ^{[1
]}

Sunnam, Sunil K. ^{[1
]}

Prasad, Kavirayani R. ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 15期

关键词：

RING-CLOSING METATHESIS; SCH725674; DITHIOLS; STRATEGY;

D O I：

10.1021/ol5018678

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantiospecific total synthesis of 14-membered macrolactone Sch 725674 was accomplished from tartaric acid. Key reactions in the synthesis include the Ley's dithiaketalization of an alkynone derived from the bis-Weinreb amide of tartaric acid, Boord olefination, and ring-closing metathesis of an acrylate ester.

引用

页码：4001 / 4003

页数：3

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