First Total Synthesis of Gliomasolide C and Formal Total Synthesis of Sch-725674

被引：18
|
作者：
Seetharamsingh, B. [1 ]
Khairnar, Pankaj V. [1 ]
Reddy, D. Srinivasa [1 ]
机构：
[1] Natl Chem Lab, Div Organ Chem, CSIR, Pune 411008, Maharashtra, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 01期
关键词：
OLEFIN METATHESIS CATALYSTS; ASYMMETRIC DIHYDROXYLATION; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; CROSS-METATHESIS; MACROLIDE; OXIDATION; FUNGUS; CELL; SEKOTHRIXIDE;
D O I：
10.1021/acs.joc.5b02318
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Syntheses of two 14-membered macrolides Sch-725674 and Gliomasolide C are described here. The first total synthesis of Gliomasolide C, the short synthesis of Sch-725674, and regios elective Wacker oxidation of internal olefin are the highlights of this disclosure. In addition, a key macrocyde with orthogonal functionalities was designed and synthesized on a gram scale for the generation of analogues.
引用
收藏
页码：290 / 296
页数：7
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