Development of a Stereospecific Strategy for the Total Synthesis of Diplodialide C and Formal Synthesis of (-)-Curvularin

被引：0
|
作者：
Kumar, Ravan [1 ]
Banerjee, Amit [1 ]
Saha, Sumit [1 ]
机构：
[1] Natl Inst Technol Sikkim, Dept Chem, Ravangla 737139, India
来源：
SYNLETT | 2025年 / 36卷 / 06期
关键词：
total synthesis; natural products; pentaketides; macrolide; epoxides; Shiina macrolactonization; STEREOSELECTIVE-SYNTHESIS;
D O I：
10.1055/s-0043-1775057
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise and efficient stereospecific approach for the total synthesis of diplodialide C (R, R and S, S isomers) has been demonstrated using chiral homoglycidol and propylene oxide as a source of starting material. Further oxidized ketolide product derived from diplodialide C (S, S isomer) was applied to the formal synthesis of (-)-curvularin following reported known literature.
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页码：679 / 682
页数：4
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