A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures

被引：0

作者：

Ooga, Mitsuharu ^{[1
]}

Sahayasheela, Vinodh J. ^{[1
]}

Hirose, Yuki ^{[1
]}

Sasaki, Daisuke ^{[1
]}

Hashiya, Kaori ^{[1
]}

Bando, Toshikazu ^{[1
]}

Sugiyama, Hiroshi ^{[2
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kitashirakawa Oiwakecho,Sakyo Ku, Kyoto 6068502, Japan

[2] Kyoto Univ, Inst Integrated Cell Mat Sci iCeMS, Yoshida Ushinomiyacho,Sakyo Ku, Kyoto, 6068501, Japan

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 66期

关键词：

DISPLACEMENT ASSAY;

D O I：

10.1039/d4cc01572j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

G-quadruplex (G4) structures play roles in various biological processes, but the challenge lies in specific targeting. To address this, we synthesized a conjugate capable of recognizing the G4 structure and its proximal duplex. Our conjugate can enable recognition of specific G4s in the human genome to understand and target those structures. The hybrid compounds we synthesized can recognize both a G-quadruplex (G4) structure and its proximal duplex region concurrently, which enables the selective recognition of a specific G4.

引用

页码：8744 / 8747

页数：4

共 50 条

[31] Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[a,g]fluorenylium derivative
Juskowiak, B
Galezowska, E
Koczorowska, N
Hermann, TW
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (14) : 3627 - 3630
[32] Design and Synthesis of 2,2′-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures
Livendahl, Madeleine
Jamroskovic, Jan
Ivanova, Svetlana
Demirel, Peter
Sabouri, Nasim
Chorell, Erik
CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (37) : 13004 - 13009
[33] Supramolecular association of a diguanidine derivative with a porphyrin-cyclodextrin conjugate and its binding to G-Quadruplex DNA
Alexander, Aleyamma
Pillai, Archana Sumohan
Akash, Bose Allben
Ananthi, Nallamuthu
Pal, Haridas
Enoch, Israel V. M. V.
Sayed, Mhejabeen
JOURNAL OF MOLECULAR STRUCTURE, 2023, 1280
[34] G-quadruplex is in human DNA
Chemical and Engineering News, 2002, 80 (35):
[35] Binding of metalloporphyrins to G-quadruplex DNA: The role of the central metal
Dejeu, Jerome
Lavergne, Thomas
Della Nora, Jeremie
Defrancq, Eric
Pratviel, Genevieve
INORGANICA CHIMICA ACTA, 2016, 452 : 98 - 103
[36] An assay for human telomeric G-quadruplex DNA binding drugs
Watkins, Derrick
Ranjan, Nihar
Kumar, Sunil
Gong, Changjun
Arya, Dev P.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (24) : 6695 - 6699
[37] G-quadruplex DNA structures in human stem cells and differentiation
Katherine G. Zyner
Angela Simeone
Sean M. Flynn
Colm Doyle
Giovanni Marsico
Santosh Adhikari
Guillem Portella
David Tannahill
Shankar Balasubramanian
Nature Communications, 13
[38] CNBP controls transcription by unfolding DNA G-quadruplex structures
David, Aldana P.
Pipier, Angelique
Pascutti, Federico
Binolfi, Andres
Weiner, Andrea M. J.
Challier, Emilse
Heckel, Sofia
Calsou, Patrick
Gomez, Dennis
Calcaterra, Nora B.
Armas, Pablo
NUCLEIC ACIDS RESEARCH, 2019, 47 (15) : 7901 - 7913
[39] Synthesis and binding studies of cationic porphyrins with G-quadruplex DNA
Barnett, Kerry L.
Le, Vu
Lewis, Edwin A.
Rowland, Gerald B.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
[40] The role of thermodynamics and kinetics in ligand binding to G-quadruplex DNA
Corry, Ben
Smith, Nicole M.
CHEMICAL COMMUNICATIONS, 2012, 48 (71) : 8958 - 8960

← 1 2 3 4 5 →