A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures

被引：0
|
作者：
Ooga, Mitsuharu [1 ]
Sahayasheela, Vinodh J. [1 ]
Hirose, Yuki [1 ]
Sasaki, Daisuke [1 ]
Hashiya, Kaori [1 ]
Bando, Toshikazu [1 ]
Sugiyama, Hiroshi [2 ]
机构：
[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kitashirakawa Oiwakecho,Sakyo Ku, Kyoto 6068502, Japan
[2] Kyoto Univ, Inst Integrated Cell Mat Sci iCeMS, Yoshida Ushinomiyacho,Sakyo Ku, Kyoto, 6068501, Japan
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 66期
关键词：
DISPLACEMENT ASSAY;
D O I：
10.1039/d4cc01572j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
G-quadruplex (G4) structures play roles in various biological processes, but the challenge lies in specific targeting. To address this, we synthesized a conjugate capable of recognizing the G4 structure and its proximal duplex. Our conjugate can enable recognition of specific G4s in the human genome to understand and target those structures. The hybrid compounds we synthesized can recognize both a G-quadruplex (G4) structure and its proximal duplex region concurrently, which enables the selective recognition of a specific G4.
引用
收藏
页码：8744 / 8747
页数：4
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