Binding of metalloporphyrins to G-quadruplex DNA: The role of the central metal

被引：12

作者：

Dejeu, Jerome ^{[1
]}

Lavergne, Thomas ^{[1
]}

Della Nora, Jeremie ^{[2
,3
]}

Defrancq, Eric ^{[1
]}

Pratviel, Genevieve ^{[2
,3
]}

机构：

[1] Univ Grenoble Alpes, Dept Chim Mol, CNRS, UMR 5250, BP 53, F-38041 Grenoble 9, France

[2] CNRS, Lab Chim Coordinat, 205 Route Narbonne,BP44099, F-31077 Toulouse 4, France

[3] Univ Toulouse, INPT, UPS, Toulouse, France

来源：

INORGANICA CHIMICA ACTA | 2016年 / 452卷

关键词：

Porphyrin; Cobalt; Nickel; Manganese; G-quadruplex DNA; GUANINE QUADRUPLEXES; CATIONIC PORPHYRINS; AQUEOUS-SOLUTION; END-STACKING; COMPLEXES; LUMINESCENT; CELLS; VISUALIZATION; TELOMERES; LIGANDS;

D O I：

10.1016/j.ica.2016.02.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two series of metalated cationic porphyrins were evaluated for their capacity to bind G-quadruplex DNA as well as for their specificity with respect to duplex DNA as a function of the metal ion inserted in the core of the porphyrin. Various metal ions (Ni2+, Co3+, Mn3+) afforded variation of the charge and axial coordination in the center of the porphyrin. The binding affinity of the metalated porphyrins toward DNA (G-quadruplex DNA and duplex DNA) was evaluated by Surface Plasmon Resonance and the influence of the metal was compared with that reported for TMPyP4. The second generation porphyrins were better G-quadruplex ligands than TMPyP4 porphyrins and, on the contrary to the TMPyP4 series, the metal had no influence on the K-D values. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：98 / 103

页数：6

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