Rational design of a red-light absorbing ruthenium polypyridine complex as a photosensitizer for photodynamic therapy

被引：4

作者：

Fennes, Alessia ^{[1
]}

Montesdeoca, Nicolas ^{[1
]}

Papadopoulos, Zisis ^{[1
]}

Karges, Johannes ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Fac Chem & Biochem, Univ Str 150, D-44780 Bochum, Germany

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 77期

关键词：

Complexation; -; Synthesis; (chemical);

D O I：

10.1039/d4cc04126g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, the computer-guided design, chemical synthesis, and biological evaluation of a Ruc polypyridine complex, that could eradicate cancerous cells upon excitation with red light at 630 nm, is reported. This study details the computer-guided design, synthesis, and biological evaluation of a Ru(ii) polypyridine complex for PDT. The complex can be excited with red light at 630 nm, showing great potential for treating large or deep-seated tumors.

引用

页码：10724 / 10727

页数：4

共 50 条

[31] Rational Design of a High-Performance Quinoxalinone-Based AIE Photosensitizer for Image-Guided Photodynamic Therapy
Zhang, Peng
Kuang, Haizhu
Xu, Yingying
Shi, Leilei
Cao, Weiling
Zhu, Kongkai
Xu, Li
Ma, Jing
ACS APPLIED MATERIALS & INTERFACES, 2020, 12 (38) : 42551 - 42557
[32] Rational design of a small organic photosensitizer for NIR-I imaging-guided synergistic photodynamic and photothermal therapy
Lv, Shibo
Liu, Yuhan
Zhao, Yanliang
Fan, Xiaoxue
Lv, Fangyuan
Feng, Erting
Liu, Dapeng
Song, Fengling
BIOMATERIALS SCIENCE, 2022, 10 (17) : 4785 - 4795
[33] Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(<sc>iii</sc>)-COUPY conjugates
Ortega-Forte, Enrique
Rovira, Anna
Ashoo, Pezhman
Izquierdo-Garcia, Eduardo
Hally, Cormac
Abad-Montero, Diego
Jorda-Redondo, Mireia
Vigueras, Gloria
Deya, Alba
Hernandez, Jose Luis
Galino, Jorge
Bosch, Manel
Alberto, Marta E.
Frances-Monerris, Antonio
Nonell, Santi
Ruiz, Jose
Marchan, Vicente
INORGANIC CHEMISTRY FRONTIERS, 2025,
[34] Can red-light 5-aminolevulinic photodynamic therapy cure port wine stains on comb animal model?
Lai, Yongxian
Zhang, Haiyan
Wei, Minglei
Jie, Ji
Shi, Lei
Wang, Peiru
Wang, Bo
Huang, Zheng
Wang, Xiuli
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2018, 22 : 253 - 262
[35] Design and Optimization of Red-light Reflector Using Simulation Software
Xu, Junjia
Lin, Chang Hong
Chen, Yu-Ting
Tseng, Hsien-Wei
Wang, Peng
Yang, Cheng-Fu
Lin, Chiang-Lung
SENSORS AND MATERIALS, 2021, 33 (08) : 2619 - 2627
[36] FAR-RED-ABSORBING PHOTOSENSITIZERS - THEIR USE IN THE PHOTODYNAMIC THERAPY OF TUMORS
JORI, G
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 1992, 62 (03) : 371 - 378
[37] Red-light induced recovery of yeast viability under the photodynamic effect of optical radiation
E. V. Pinyaskina
N. S. Belenikina
G. Ya. Fraikin
A. B. Rubin
Moscow University Biological Sciences Bulletin, 2007, 62 (1) : 26 - 29
[38] The Use of Inorganic Compounds in Photodynamic Therapy: Improvements in Methods and Photosensitizer Design
Boodram, Shivani
Bullock, Jimmie L.
Rambaran, Varma H.
Holder, Alvin A.
RECENT PATENTS ON NANOTECHNOLOGY, 2017, 11 (01) : 3 - 14
[39] Red-Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage
Bretin, Ludovic
Husiev, Yurii
Ramu, Vadde
Zhang, Liyan
Hakkennes, Matthijs
Abyar, Selda
Johns, Andrew C.
Le Devedec, Sylvia E.
Betancourt, Tania
Kornienko, Alexander
Bonnet, Sylvestre
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2024, 63 (05)
[40] An Alkynyl-Dangling Ru(II) Polypyridine Complex for Targeted Antimicrobial Photodynamic Therapy
Jian, Yao
Jin, Zhihui
Qi, Shuang
Da, Xuwen
Wang, Zhanhua
Wang, Xuesong
Zhou, Qianxiong
CHEMISTRY-A EUROPEAN JOURNAL, 2022, 28 (06)

← 1 2 3 4 5 →