Neutralization of SARS-CoV-2 Omicron subvariant BA.2.87.1

被引：7
|
作者：
Lasrado, Ninaad [1 ]
Rossler, Annika [1 ]
Rowe, Marjorie [1 ]
Collier, Ai-ris Y. [1 ]
Barouch, Dan H. [1 ,2 ]
机构：
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA USA
[2] Ctr Virol & Vaccine Res, 330 Brookline Ave,E-CLS-1043, Boston, MA 02115 USA
来源：
VACCINE | 2024年 / 42卷 / 09期
关键词：
SARS-CoV-2; Omicron; BA.2.87.1; Neutralizing antibody; mRNA;
D O I：
10.1016/j.vaccine.2024.03.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A new highly mutated Omicron subvariant BA.2.87.1 has recently been identified with over 30 amino acid mutations in the Spike protein compared with BA.2, BA.5, XBB.1.5, and JN.1 variants. Mutiple mutations in BA.2.87.1 are located in the N -terminal domain (NTD) rather than in the receptor binding domain (RBD) of the Spike protein. We evaluated neutralizing antibody (NAb) responses to BA.2.87.1 because of its highly mutated sequence and its unique NTD region. Our data show that NAb responses to BA.2.87.1 were lower than to BA.2 but higher than to JN.1, suggesting that BA.2.87.1 is not a further antibody escape variant compared with other currently circulating variants. Moreover, XBB.1.5 mRNA boosting increased NAb titers to all variants tested including BA.2.87.1.
引用
收藏
页码：2117 / 2121
页数：5
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