Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86

被引：42

作者：

Lasrado, Ninaad ^{[1
]}

Collier, Ai-ris Y. ^{[1
]}

Hachmann, Nicole P. ^{[1
]}

Miller, Jessica ^{[1
]}

Rowe, Marjorie ^{[1
]}

Schonberg, Eleanor D. ^{[1
]}

Rodrigues, Stefanie L. ^{[1
]}

LaPiana, Austin ^{[1
]}

Patio, Robert C. ^{[1
]}

Anand, Trisha ^{[1
]}

Fisher, Jana ^{[1
]}

Mazurek, Camille R. ^{[1
]}

Guan, Ruoran ^{[1
]}

Wagh, Kshitij ^{[2
]}

Theiler, James ^{[2
]}

Korber, Bette T. ^{[2
]}

Barouch, Dan H. ^{[1
,3
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Boston, MA USA

[2] Los Alamos Natl Labs, Santa Fe, NM USA

[3] Ctr Virol & Vaccine Res, 330 Brookline Ave, E-CLS-1043, Boston, MA 02115 USA

来源：

VACCINE | 2023年 / 41卷 / 47期

关键词：

SARS-CoV-2; BA.2.86; Vaccine; Neutralizing antibody; mRNA;

D O I：

10.1016/j.vaccine.2023.10.051

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant BA.2.86 has over 30 mutations in spike compared with BA.2 and XBB.1.5, which raised the possibility that BA.2.86 might evade neutralizing antibodies (NAbs) induced by vaccination or infection. In this study, we show that NAb titers are substantially lower to BA.2.86 compared with BA.2 but are similar or slightly higher than to other current circulating variants, including XBB.1.5, EG.5.1, and FL.1.5.1. Moreover, NAb titers against all these variants were higher in vaccinated individuals with a history of XBB.1.5 infection compared with vaccinated individuals with no history of XBB.1.5 infection, suggesting the potential utility of the monovalent XBB.1.5 mRNA boosters.

引用

页码：6904 / 6909

页数：6

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