Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86

被引：42

作者：

Lasrado, Ninaad ^{[1
]}

Collier, Ai-ris Y. ^{[1
]}

Hachmann, Nicole P. ^{[1
]}

Miller, Jessica ^{[1
]}

Rowe, Marjorie ^{[1
]}

Schonberg, Eleanor D. ^{[1
]}

Rodrigues, Stefanie L. ^{[1
]}

LaPiana, Austin ^{[1
]}

Patio, Robert C. ^{[1
]}

Anand, Trisha ^{[1
]}

Fisher, Jana ^{[1
]}

Mazurek, Camille R. ^{[1
]}

Guan, Ruoran ^{[1
]}

Wagh, Kshitij ^{[2
]}

Theiler, James ^{[2
]}

Korber, Bette T. ^{[2
]}

Barouch, Dan H. ^{[1
,3
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Boston, MA USA

[2] Los Alamos Natl Labs, Santa Fe, NM USA

[3] Ctr Virol & Vaccine Res, 330 Brookline Ave, E-CLS-1043, Boston, MA 02115 USA

来源：

VACCINE | 2023年 / 41卷 / 47期

关键词：

SARS-CoV-2; BA.2.86; Vaccine; Neutralizing antibody; mRNA;

D O I：

10.1016/j.vaccine.2023.10.051

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant BA.2.86 has over 30 mutations in spike compared with BA.2 and XBB.1.5, which raised the possibility that BA.2.86 might evade neutralizing antibodies (NAbs) induced by vaccination or infection. In this study, we show that NAb titers are substantially lower to BA.2.86 compared with BA.2 but are similar or slightly higher than to other current circulating variants, including XBB.1.5, EG.5.1, and FL.1.5.1. Moreover, NAb titers against all these variants were higher in vaccinated individuals with a history of XBB.1.5 infection compared with vaccinated individuals with no history of XBB.1.5 infection, suggesting the potential utility of the monovalent XBB.1.5 mRNA boosters.

引用

页码：6904 / 6909

页数：6

共 50 条

[31] Sensitivity of the SARS-CoV-2 BA.2.86 variant to prevailing neutralising antibody responses
Sheward, Daniel J.
Yang, Yiqiu
Westerberg, Michelle
Oling, Sofia
Muschiol, Sandra
Sato, Kenta
Peacock, Thomas P.
Hedestam, Gunilla B. Karlsson
Albert, Jan
Murrell, Ben
[J]. LANCET INFECTIOUS DISEASES, 2023, 23 (11): : 462 - 463
[32] Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6
Aiste Dijokaite-Guraliuc
Raksha Das
Rungtiwa Nutalai
Daming Zhou
Alexander J. Mentzer
Chang Liu
Piyada Supasa
Susanna J. Dunachie
Teresa Lambe
Elizabeth E. Fry
Juthathip Mongkolsapaya
Jingshan Ren
Jiandong Huo
David I. Stuart
Gavin R. Screaton
[J]. Cell Discovery, 8
[33] Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6
Dijokaite-Guraliuc, Aiste
Das, Raksha
Nutalai, Rungtiwa
Zhou, Daming
Mentzer, Alexander J.
Liu, Chang
Supasa, Piyada
Dunachie, Susanna J.
Lambe, Teresa
Fry, Elizabeth E.
Mongkolsapaya, Juthathip
Ren, Jingshan
Huo, Jiandong
Stuart, David I.
Screaton, Gavin R.
[J]. CELL DISCOVERY, 2022, 8 (01)
[34] Omicron BA.2.86 Pirola nightmare: Empirical formulas and thermodynamic properties (enthalpy, entropy and Gibbs energy change) of nucleocapsid, virus particle and biosynthesis of BA.2.86 Pirola variant of SARS-CoV-2
University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, Belgrade
11000, Serbia
不详
11000, Serbia
不详
[J]. J. Serb. Chem. Soc., 6 (807-822):
[35] Virus isolation and neutralisation of SARS-CoV-2 variants BA.2.86 and EG.5.1
Lassauniere, Ria
Polacek, Charlotta
Utko, Magdalena
Sorensen, Karina M.
Baig, Sharmin
Ellegaard, Kirsten
Escobar-Herrera, Leandro A.
Fomsgaard, Anders
Spiess, Katja
Gunalan, Vithiagaran
Bennedbaek, Marc
Fonager, Jannik
Schwartz, Olivier
Planas, Delphine
Simon-Loriere, Etienne
Schneider, Uffe, V
Sieber, Raphael N.
Stegger, Marc
Nielsen, Lene
Hoppe, Morten
Krause, Tyra G.
Ullum, Henrik
Jokelainen, Pikka
Rasmussen, Morten
[J]. LANCET INFECTIOUS DISEASES, 2023, 23 (12): : E509 - E510
[36] Omicron BA.2.86 Pirola nightmare: Empirical formulas and thermodynamic properties (enthalpy, entropy and Gibbs energy change) of nucleocapsid, virus particle and biosynthesis of BA.2.86 Pirola variant of SARS-CoV-2
Popovic, Marko E.
Popovic, Marta
Sekularac, Gavrilo
Pavlovic, Marijana Pantovic
[J]. JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2024, 89 (06) : 807 - 822
[37] A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity
Liu, Chang
Zhou, Daming
Dijokaite-Guraliuc, Aiste
Supasa, Piyada
Duyvesteyn, Helen M. E.
Ginn, Helen M.
Selvaraj, Muneeswaran
Mentzer, Alexander J.
Das, Raksha
de Silva, Thushan I.
Ritter, Thomas G.
Plowright, Megan
Newman, Thomas A. H.
Stafford, Lizzie
Kronsteiner, Barbara
Temperton, Nigel
Lui, Yuan
Fellermeyer, Martin
Goulder, Philip
Klenerman, Paul
Dunachie, Susanna J.
Barton, Michael I.
Kutuzov, Mikhail A.
Dushek, Omer
Fry, Elizabeth E.
Mongkolsapaya, Juthathip
Ren, Jingshan
Stuart, David I.
Screaton, Gavin R.
[J]. CELL REPORTS MEDICINE, 2024, 5 (05)
[38] Increased faecal shedding in SARS-CoV-2 variants BA.2.86 and JN.1
Wannigama, Dhammika Leshan
Amarasiri, Mohan
Phattharapornjaroen, Phatthranit
Hurst, Cameron
Modchang, Charin
Chadsuthi, Sudarat
Anupong, Suparinthon
Miyanaga, Kazuhiko
Cui, Longzhu
Fernandez, Stefan
Huang, Angkana
Ounjai, Puey
Singer, Andrew C.
Ragupathi, Naveen Kumar Devanga
Sano, Daisuke
Furukawa, Takashi
Sei, Kazunari
Leelahavanichkul, Asada
Kanjanabuch, Talerngsak
Chatsuwan, Tanittha
Higgins, Paul G.
Nanbo, Asuka
Kicic, Anthony
Siow, Richard
Trowsdale, Sam
Hongsing, Parichart
Khatib, Aisha
Shibuya, Kenji
Abe, Shuichi
Ishikawa, Hitoshi
[J]. LANCET INFECTIOUS DISEASES, 2024, 24 (06): : e348 - e350
[39] The highly mutated SARS-CoV-2 variant BA.2.86 is still neutralized by antibodies in the blood
Wang, Qian
Ho, David D.
[J]. NATURE, 2023,
[40] Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5
Hachmann, Nicole P.
Miller, Jessica
Collier, Ai-ris Y.
Ventura, John D.
Yu, Jingyou
Rowe, Marjorie
Bondzie, Esther A.
Powers, Olivia
Surve, Nehalee
Hall, Kevin
Barouch, Dan H.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (01): : 86 - 88

← 1 2 3 4 5 →