Virological Traits of the SARS-CoV-2 BA.2.87.1 Lineage

被引：3

作者：

Zhang, Lu ^{[1
,2
]}

Dopfer-Jablonka, Alexandra ^{[3
,4
]}

Nehlmeier, Inga ^{[1
]}

Kempf, Amy ^{[1
,2
]}

Graichen, Luise ^{[1
,2
]}

Calderon Hampel, Noemi ^{[3
]}

Cossmann, Anne ^{[3
]}

Stankov, Metodi V. ^{[3
]}

Morillas Ramos, Gema ^{[3
]}

Schulz, Sebastian R. ^{[5
]}

Jaeck, Hans-Martin ^{[5
]}

Behrens, Georg M. N. ^{[3
,4
,6
]}

Poehlmann, Stefan ^{[1
,2
]}

Hoffmann, Markus ^{[1
,2
]}

机构：

[1] Leibniz Inst Primate Res, Infect Biol Unit, German Primate Ctr, D-37077 Gottingen, Germany

[2] Georg August Univ Gottingen, Fac Biol & Psychol, D-37073 Gottingen, Germany

[3] Hannover Med Sch, Dept Rheumatol & Immunol, D-30625 Hannover, Germany

[4] German Ctr Infect Res DZ, Partner Site Hannover Braunschweig, D-30625 Hannover, Germany

[5] Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med 3, Div Mol Immunol, D-91054 Erlangen, Germany

[6] Ctr Individualized Infect Med CiiM, D-30625 Hannover, Germany

来源：

VACCINES | 2024年 / 12卷 / 05期

关键词：

SARS-CoV-2; BA.2.87.1; spike protein; host cell entry; ACE2; binding; antibody evasion; COVID-19; VACCINE;

D O I：

10.3390/vaccines12050487

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transmissibility and immune evasion of the recently emerged, highly mutated SARS-CoV-2 BA.2.87.1 are unknown. Here, we report that BA.2.87.1 efficiently enters human cells but is more sensitive to antibody-mediated neutralization than the currently dominating JN.1 variant. Acquisition of adaptive mutations might thus be needed for efficient spread in the population.

引用

页数：14

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