Neutralization of SARS-CoV-2 Omicron subvariant BA.2.87.1

被引：7
|
作者：
Lasrado, Ninaad [1 ]
Rossler, Annika [1 ]
Rowe, Marjorie [1 ]
Collier, Ai-ris Y. [1 ]
Barouch, Dan H. [1 ,2 ]
机构：
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA USA
[2] Ctr Virol & Vaccine Res, 330 Brookline Ave,E-CLS-1043, Boston, MA 02115 USA
来源：
VACCINE | 2024年 / 42卷 / 09期
关键词：
SARS-CoV-2; Omicron; BA.2.87.1; Neutralizing antibody; mRNA;
D O I：
10.1016/j.vaccine.2024.03.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A new highly mutated Omicron subvariant BA.2.87.1 has recently been identified with over 30 amino acid mutations in the Spike protein compared with BA.2, BA.5, XBB.1.5, and JN.1 variants. Mutiple mutations in BA.2.87.1 are located in the N -terminal domain (NTD) rather than in the receptor binding domain (RBD) of the Spike protein. We evaluated neutralizing antibody (NAb) responses to BA.2.87.1 because of its highly mutated sequence and its unique NTD region. Our data show that NAb responses to BA.2.87.1 were lower than to BA.2 but higher than to JN.1, suggesting that BA.2.87.1 is not a further antibody escape variant compared with other currently circulating variants. Moreover, XBB.1.5 mRNA boosting increased NAb titers to all variants tested including BA.2.87.1.
引用
收藏
页码：2117 / 2121
页数：5
相关论文
共 50 条
  • [11] Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6
    Aiste Dijokaite-Guraliuc
    Raksha Das
    Rungtiwa Nutalai
    Daming Zhou
    Alexander J. Mentzer
    Chang Liu
    Piyada Supasa
    Susanna J. Dunachie
    Teresa Lambe
    Elizabeth E. Fry
    Juthathip Mongkolsapaya
    Jingshan Ren
    Jiandong Huo
    David I. Stuart
    Gavin R. Screaton
    [J]. Cell Discovery, 8
  • [12] Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6
    Dijokaite-Guraliuc, Aiste
    Das, Raksha
    Nutalai, Rungtiwa
    Zhou, Daming
    Mentzer, Alexander J.
    Liu, Chang
    Supasa, Piyada
    Dunachie, Susanna J.
    Lambe, Teresa
    Fry, Elizabeth E.
    Mongkolsapaya, Juthathip
    Ren, Jingshan
    Huo, Jiandong
    Stuart, David I.
    Screaton, Gavin R.
    [J]. CELL DISCOVERY, 2022, 8 (01)
  • [13] Evolution and neutralization escape of the SARS-CoV-2 BA.2.86 subvariant
    Khadija Khan
    Gila Lustig
    Cornelius Römer
    Kajal Reedoy
    Zesuliwe Jule
    Farina Karim
    Yashica Ganga
    Mallory Bernstein
    Zainab Baig
    Laurelle Jackson
    Boitshoko Mahlangu
    Anele Mnguni
    Ayanda Nzimande
    Nadine Stock
    Dikeledi Kekana
    Buhle Ntozini
    Cindy van Deventer
    Terry Marshall
    Nithendra Manickchund
    Bernadett I. Gosnell
    Richard J. Lessells
    Quarraisha Abdool Karim
    Salim S. Abdool Karim
    Mahomed-Yunus S. Moosa
    Tulio de Oliveira
    Anne von Gottberg
    Nicole Wolter
    Richard A. Neher
    Alex Sigal
    [J]. Nature Communications, 14
  • [14] Evolution and neutralization escape of the SARS-CoV-2 BA.2.86 subvariant
    Khan, Khadija
    Lustig, Gila
    Romer, Cornelius
    Reedoy, Kajal
    Jule, Zesuliwe
    Karim, Farina
    Ganga, Yashica
    Bernstein, Mallory
    Baig, Zainab
    Jackson, Laurelle
    Mahlangu, Boitshoko
    Mnguni, Anele
    Nzimande, Ayanda
    Stock, Nadine
    Kekana, Dikeledi
    Ntozini, Buhle
    van Deventer, Cindy
    Marshall, Terry
    Manickchund, Nithendra
    Gosnell, Bernadett I.
    Lessells, Richard J.
    Karim, Quarraisha Abdool
    Karim, Salim S. Abdool
    Moosa, Mahomed-Yunus S.
    de Oliveira, Tulio
    von Gottberg, Anne
    Wolter, Nicole
    Neher, Richard A.
    Sigal, Alex
    [J]. NATURE COMMUNICATIONS, 2023, 14 (01)
  • [15] Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies
    Wang, Xun
    Jiang, Shujun
    Ma, Wentai
    Zhang, Yanliang
    Wang, Pengfei
    [J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 9 (01)
  • [16] Resistance of SARS-CoV-2 omicron subvariant BA.4.6 to antibody neutralisation
    Wang, Qian
    Li, Zhiteng
    Ho, Jerren
    Guo, Yicheng
    Yeh, Andre Yanchen
    Mohri, Hiroshi
    Liu, Michael
    Wang, Maple
    Yu, Jian
    Shah, Jayesh G.
    Chang, Jennifer Y.
    Herbas, Favio
    Yin, Michael T.
    Sobieszczyk, Magdalena E.
    Sheng, Zizhang
    Liu, Lihong
    Ho, David
    [J]. LANCET INFECTIOUS DISEASES, 2022, 22 (12): : 1666 - 1668
  • [17] Estimates of SARS-CoV-2 Omicron BA.2 Subvariant Severity in New England
    Strasser, Zachary H.
    Greifer, Noah
    Hadavand, Aboozar
    Murphy, Shawn N.
    Estiri, Hossein
    [J]. JAMA NETWORK OPEN, 2022, 5 (10) : E2238354
  • [18] Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2
    Takashita, Emi
    Kinoshita, Noriko
    Yamayoshi, Seiya
    Sakai-Tagawa, Yuko
    Fujisaki, Seiichiro
    Ito, Mutsumi
    Iwatsuki-Horimoto, Kiyoko
    Halfmann, Peter
    Watanabe, Shinji
    Maeda, Kenji
    Imai, Masaki
    Mitsuya, Hiroaki
    Ohmagari, Norio
    Takeda, Makoto
    Hasegawa, Hideki
    Kawaoka, Yoshihiro
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (15): : 1475 - 1477
  • [19] SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
    Xinling Wang
    Lu Lu
    Shibo Jiang
    [J]. Signal Transduction and Targeted Therapy, 8
  • [20] Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants
    Yu, Jingyou
    Collier, Ai-ris Y.
    Rowe, Marjorie
    Mardas, Fatima
    Ventura, John D.
    Wan, Huahua
    Miller, Jessica
    Powers, Olivia
    Chung, Benjamin
    Siamatu, Mazuba
    Hachmann, Nicole P.
    Surve, Nehalee
    Nampanya, Felix
    Chandrashekar, Abishek
    Barouch, Dan H.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (16):
12345