A lateral flow assay strip for simultaneous detection of miRNA and exosomes in liver cancer

被引：3

作者：

Wei, Ruyue ^{[1
]}

Wang, Dawei ^{[3
,4
]}

Zhou, Ping ^{[1
]}

Pan, Yingbo ^{[1
]}

Wan, Xiuyan ^{[1
]}

Pan, Wei ^{[1
]}

Li, Na ^{[1
]}

Tang, Bo ^{[1
,2
]}

机构：

[1] Shandong Normal Univ, Univ Shandong, Minist Educ, Coll Chem Chem Engn & Mat Sci,Inst Mol & Nano Sci,, Jinan 250014, Peoples R China

[2] Laoshan Lab, Qingdao 266237, Peoples R China

[3] Shandong First Med Univ, Affiliated Hosp 1, Dept Hlth Management, Jinan 250014, Peoples R China

[4] Shandong Prov Qianfoshan Hosp, Shandong Engn Lab Hlth Management, Shandong Med & Hlth Key Lab Lab Med, Jinan 250014, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 58期

基金：

中国国家自然科学基金;

关键词：

Diseases;

D O I：

10.1039/d4cc02559h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By employing an aptamer as the bridge and combining catalytic hairpin assembly with the Au aggregation amplification effect, a lateral flow assay (LFA) is designed for simultaneous detection of liver cancer-associated miRNA and exosomes. The LFA can differentiate between liver cancer patients and healthy individuals with simple operation and high accuracy. We demonstrate a lateral flow assay (LFA) to achieve the simultaneous detection of liver cancer-associated miRNA and exosomes by employing an aptamer as the bridge and combining catalytic hairpin assembly with the Au aggregation amplification effect.

引用

页码：7491 / 7494

页数：4

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