A lateral flow assay strip for simultaneous detection of miRNA and exosomes in liver cancer

被引：3
|
作者：
Wei, Ruyue [1 ]
Wang, Dawei [3 ,4 ]
Zhou, Ping [1 ]
Pan, Yingbo [1 ]
Wan, Xiuyan [1 ]
Pan, Wei [1 ]
Li, Na [1 ]
Tang, Bo [1 ,2 ]
机构：
[1] Shandong Normal Univ, Univ Shandong, Minist Educ, Coll Chem Chem Engn & Mat Sci,Inst Mol & Nano Sci,, Jinan 250014, Peoples R China
[2] Laoshan Lab, Qingdao 266237, Peoples R China
[3] Shandong First Med Univ, Affiliated Hosp 1, Dept Hlth Management, Jinan 250014, Peoples R China
[4] Shandong Prov Qianfoshan Hosp, Shandong Engn Lab Hlth Management, Shandong Med & Hlth Key Lab Lab Med, Jinan 250014, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 58期
基金：
中国国家自然科学基金;
关键词：
Diseases;
D O I：
10.1039/d4cc02559h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
By employing an aptamer as the bridge and combining catalytic hairpin assembly with the Au aggregation amplification effect, a lateral flow assay (LFA) is designed for simultaneous detection of liver cancer-associated miRNA and exosomes. The LFA can differentiate between liver cancer patients and healthy individuals with simple operation and high accuracy. We demonstrate a lateral flow assay (LFA) to achieve the simultaneous detection of liver cancer-associated miRNA and exosomes by employing an aptamer as the bridge and combining catalytic hairpin assembly with the Au aggregation amplification effect.
引用
收藏
页码：7491 / 7494
页数：4
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