Synthesis of acridones via Ir(<sc>iii</sc>)-catalyzed amination annulation of oxazoles with anthranils

被引：0

作者：

Zhou, Han-Yi ^{[1
,2
]}

Dong, Lin ^{[1
,2
]}

机构：

[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug, Educ Minist & Sichuan Prov, Chengdu 610041, Peoples R China

[2] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 20期

关键词：

METAL-FREE SYNTHESIS; BOND-CLEAVAGE; FUNCTIONALIZATION; CHALLENGES; DESIGN;

D O I：

10.1039/d4ob00377b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented Ir(iii)-catalyzed C-H activation/amination/annulation of 2-phenyloxazoles with anthranils for the highly selective preparation of acridone derivatives in one-pot under controlled conditions is reported. This protocol is characterized by atom economy and high regioselectivity. A wide range of anthranils with 2-phenyloxazoles were well tolerated and afforded the desired products in moderate to good yields, in which the anthranil serves as a convenient amination reagent.

引用

页码：4036 / 4040

页数：5

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