QSAR STUDY OF ORTHO-PHENYLPHENOL LEUKOTRIENE B4 RECEPTOR ANTAGONISTS

被引：2

作者：

WIKEL, JH

SOFIA, MJ

SAUSSY, DL

BEMIS, KG

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)80850-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

QSAR models for a series of o-phenylphenol LTB4 receptor antagonist have been developed with regression analysis. These models related specific features, electronic, size and shape, of the substituent with biological activity. The models have predictive value and may be useful in assisting future synthetic direction within this series of compounds.

引用

页码：795 / 800

页数：6

共 50 条

[31] ORTHO-ALKOXYPHENOL LEUKOTRIENE B-4 RECEPTOR ANTAGONISTS - EFFECT OF A CHROMAN CARBOXYLIC-ACID
SOFIA, MJ
SAUSSY, DL
JACKSON, WT
MARDER, P
SILBAUGH, SA
FROELICH, LL
COCKERHAM, SL
STENGEL, PW
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (12) : 1675 - 1680
[32] Structural Analysis of Leukotriene B4 (LBT4) Receptor (BLT1 AND BLT2) Antagonists
Khairullina, V. R.
Taipov, I. A.
Gerchikov, A. Ya.
Vasil'ev, M. N.
Zarudii, F. S.
Boegel, H.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2014, 48 (05) : 317 - 322
[33] Structural Analysis of Leukotriene B4 (LBT4) Receptor (BLT1 AND BLT2) Antagonists
V. R. Khairullina
I. A. Taipov
A. Ya. Gerchikov
M. N. Vasil’ev
F. S. Zarudii
H. Boegel
Pharmaceutical Chemistry Journal, 2014, 48 : 317 - 322
[34] A novel hepatointestinal leukotriene B4 receptor -: Cloning and functional characterization
Wang, SK
Gustafson, E
Pang, L
Qiao, XD
Behan, J
Maguire, M
Bayne, M
Laz, T
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (52) : 40686 - 40694
[35] Targeting leukotriene B4 in inflammation
Di Gennaro, Antonio
Haeggstrom, Jesper Z.
EXPERT OPINION ON THERAPEUTIC TARGETS, 2014, 18 (01) : 79 - 93
[36] Metabolism and receptors of leukotriene B4
Yokomizo, T
SEIKAGAKU, 2002, 74 (09): : 1139 - 1147
[37] Role of leukotriene B4 receptor signaling in human preadipocyte differentiation
Hirata, Kae
Katayama, Kazufumi
Nakajima, Atsushi
Takada, Kenji
Kamisaki, Yoshinori
Wada, Koichiro
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 429 (3-4) : 197 - 203
[38] CHIRAL SYNTHESIS OF LEUKOTRIENE B4
Yan Fang WANG
Jin Cui LI
Yu Lin WU
(State key Laboratory of Bio-organic and Natural Products
Li Lan SHI
Yao Zeng HUANG (Laboratory
Chinese Chemical Letters, 1994, (06) : 459 - 460
[39] trans-3-benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor
Reiter, LA
Koch, K
Piscopio, AD
Showell, HJ
Alpert, R
Biggers, MS
Chambers, RJ
Conklyn, MJ
Cooper, K
Cortina, SR
Dibrino, JN
Dominy, BW
Farrell, CA
Hingorani, GP
Martinelli, GJ
Ramchandani, M
Wright, KF
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (14) : 1781 - 1786
[40] Receptor for advanced glycation endproducts modulates leukotriene B4 receptor 1 signaling
Ichiki, Takako
Koga, Tomoaki
Okuno, Toshiaki
Saeki, Kazuko
Yamamoto, Yasuhiko
Sakaguchi, Masakiyo
Yokomizo, Takehiko
FASEB JOURNAL, 2016, 30

← 1 2 3 4 5 →