Role of leukotriene B4 receptor signaling in human preadipocyte differentiation

被引：6
|
作者：
Hirata, Kae [1 ,2 ]
Katayama, Kazufumi [1 ]
Nakajima, Atsushi [3 ]
Takada, Kenji [2 ]
Kamisaki, Yoshinori [1 ]
Wada, Koichiro [1 ]
机构：
[1] Osaka Univ, Grad Sch Dent, Dept Pharmacol, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Dent, Dept Orthodont & Dentofacial Orthoped, Suita, Osaka 5650871, Japan
[3] Yokohama City Univ, Sch Med, Div Gastroenterol, Yokohama, Kanagawa 2360004, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 429卷 / 3-4期
基金：
日本学术振兴会;
关键词：
Leukotriene; Receptor; Adipocyte; Preadipocyte; Differentiation; siRNA; TGFBI; Human; ADENOCARCINOMA CELL-LINE; INSULIN-RESISTANCE; PROLIFERATION; LIPOXIN; BIOSYNTHESIS; BETA-IG-H3; PATHWAY; PROTEIN; OBESITY; GAMMA;
D O I：
10.1016/j.bbrc.2012.10.110
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the role of leukotriene B-4 (LTB4)-leukotriene receptor (BLT) signaling in preadipocyte differentiation into mature adipocytes. Blockade of BLT signaling by treatment with lipoxygenase inhibitors, a BLT antagonist, and small interfering RNAs for BLTs in human and mouse preadipocytes isolated from adipose tissues showed acceleration of differentiation into mature adipocytes. DNA microarray analysis revealed regulation of transforming growth factor, beta-induced 68 kDa (TGFBI) expression through the BLT signaling pathway during adipocyte differentiation. Knockdown of TGFBI also showed acceleration of preadipocyte differentiation. The LTB4-BLT signaling pathway may negatively regulate preadipocyte differentiation via induction of TGFBI expression as a rate-limiting system to control adipocyte differentiation. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：197 / 203
页数：7
相关论文
共 50 条
  • [1] Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation
    Kae Hirata
    Koichiro Wada
    Yuka Murata
    Atsushi Nakajima
    Takashi Yamashiro
    Yoshinori Kamisaki
    Lipids in Health and Disease, 12
  • [2] Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation
    Hirata, Kae
    Wada, Koichiro
    Murata, Yuka
    Nakajima, Atsushi
    Yamashiro, Takashi
    Kamisaki, Yoshinori
    LIPIDS IN HEALTH AND DISEASE, 2013, 12
  • [3] Leukotriene B4 receptor -: Cloning and intracellular signaling
    Yokomizo, T
    Masuda, K
    Kato, K
    Toda, A
    Izumi, T
    Shimizu, T
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (02) : S51 - S55
  • [4] Leukotriene B4 is a regulatory signal for human adipocytes differentiation
    Hirata, Kae
    Wada, Koichiro
    Takada, Kenji
    Kamisaki, Yoshinori
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112 : 162P - 162P
  • [5] The role of leukotriene B4 receptor 1 in myocardial infarction
    Nakaya, Michio
    Kurose, Hitoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015, 128 (03) : S28 - S28
  • [6] The role of leukotriene B4 receptor 1 in myocardial infarction
    Nishihara, Hiroaki
    Nakaya, Michio
    Watari, Kenji
    Kurose, Hitoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124 : 87P - 87P
  • [7] Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes
    Chen, L. Y.
    Eberlein, M.
    Alsaaty, S.
    Martinez-Anton, A.
    Barb, J.
    Munson, P. J.
    Danner, R. L.
    Liu, Y.
    Logun, C.
    Shelhamer, J. H.
    Woszczek, G.
    ALLERGY, 2011, 66 (10) : 1304 - 1311
  • [8] Leukotriene B4 signaling in diabetic retinopathy
    Gubitosi-Klug, Rosea.
    Talahalli, Ramaprasad
    DIABETES, 2007, 56 : A220 - A220
  • [9] Receptor for advanced glycation endproducts modulates leukotriene B4 receptor 1 signaling
    Ichiki, Takako
    Koga, Tomoaki
    Okuno, Toshiaki
    Saeki, Kazuko
    Yamamoto, Yasuhiko
    Sakaguchi, Masakiyo
    Yokomizo, Takehiko
    FASEB JOURNAL, 2016, 30
  • [10] Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4
    Nakanishi, Yoshimitsu
    Tan, Modong
    Ichiki, Takako
    Inoue, Asuka
    Yoshihara, Jun-ichi
    Maekawa, Naoto
    Takenoshita, Itsuki
    Yanagida, Keisuke
    Yamahira, Shinya
    Yamaguchi, Satoshi
    Aoki, Junken
    Nagamune, Teruyuki
    Yokomizo, Takehiko
    Shimizu, Takao
    Nakamura, Motonao
    SCIENCE SIGNALING, 2018, 11 (544)
12345