Role of leukotriene B4 receptor signaling in human preadipocyte differentiation

被引：6
|
作者：
Hirata, Kae [1 ,2 ]
Katayama, Kazufumi [1 ]
Nakajima, Atsushi [3 ]
Takada, Kenji [2 ]
Kamisaki, Yoshinori [1 ]
Wada, Koichiro [1 ]
机构：
[1] Osaka Univ, Grad Sch Dent, Dept Pharmacol, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Dent, Dept Orthodont & Dentofacial Orthoped, Suita, Osaka 5650871, Japan
[3] Yokohama City Univ, Sch Med, Div Gastroenterol, Yokohama, Kanagawa 2360004, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 429卷 / 3-4期
基金：
日本学术振兴会;
关键词：
Leukotriene; Receptor; Adipocyte; Preadipocyte; Differentiation; siRNA; TGFBI; Human; ADENOCARCINOMA CELL-LINE; INSULIN-RESISTANCE; PROLIFERATION; LIPOXIN; BIOSYNTHESIS; BETA-IG-H3; PATHWAY; PROTEIN; OBESITY; GAMMA;
D O I：
10.1016/j.bbrc.2012.10.110
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the role of leukotriene B-4 (LTB4)-leukotriene receptor (BLT) signaling in preadipocyte differentiation into mature adipocytes. Blockade of BLT signaling by treatment with lipoxygenase inhibitors, a BLT antagonist, and small interfering RNAs for BLTs in human and mouse preadipocytes isolated from adipose tissues showed acceleration of differentiation into mature adipocytes. DNA microarray analysis revealed regulation of transforming growth factor, beta-induced 68 kDa (TGFBI) expression through the BLT signaling pathway during adipocyte differentiation. Knockdown of TGFBI also showed acceleration of preadipocyte differentiation. The LTB4-BLT signaling pathway may negatively regulate preadipocyte differentiation via induction of TGFBI expression as a rate-limiting system to control adipocyte differentiation. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：197 / 203
页数：7
相关论文
共 50 条
  • [31] Cloning and characterization of rat leukotriene B4 receptor
    Toda, A
    Yokomizo, T
    Masuda, K
    Nakao, A
    Izumi, T
    Shimizu, T
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 262 (03) : 806 - 812
  • [32] Cloning and characterization of cDNA encoding a novel human leukotriene B4 receptor
    Tryselius, Y
    Nilsson, NE
    Kotarsky, K
    Olde, B
    Owman, C
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 274 (02) : 377 - 382
  • [33] Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE)
    Ichiki, Takako
    Koga, Tomoaki
    Okuno, Toshiaki
    Saeki, Kazuko
    Yamamoto, Yasuhiko
    Yamamoto, Hiroshi
    Sakaguchi, Masakiyo
    Yokomizo, Takehiko
    FASEB JOURNAL, 2016, 30 (05): : 1811 - 1822
  • [34] Leukotriene B4 Potentiates CpG Signaling for Enhanced Cytokine Secretion by Human Leukocytes
    Gaudreault, Eric
    Gosselin, Jean
    JOURNAL OF IMMUNOLOGY, 2009, 183 (04): : 2650 - 2658
  • [35] Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice
    Kamata, Mariko
    Amano, Hideki
    Ito, Yoshiya
    Fujita, Tomoe
    Otaka, Fumisato
    Hosono, Kanako
    Kamata, Kouju
    Takeuchi, Yasuo
    Yokomizo, Takehiko
    Shimizu, Takao
    Majima, Masataka
    PLOS ONE, 2019, 14 (02):
  • [36] Role of leukotriene B4 receptors in rheumatoid arthritis
    Mathis, Steven
    Jala, Venkatakrishna R.
    Haribabu, Bodduluri
    AUTOIMMUNITY REVIEWS, 2007, 7 (01) : 12 - 17
  • [37] Quantification of leukotriene B4 glucuronide in human urine
    Mita, Haruhisa
    Turikisawa, Naomi
    Yamada, Tetsuo
    Taniguchi, Masami
    PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2007, 83 (1-2) : 42 - 49
  • [38] LEUKOTRIENE B4 INDUCES HUMAN SUPPRESSOR LYMPHOCYTES
    ROLAPLESZCZYNSKI, M
    BORGEAT, P
    SIROIS, P
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 108 (04) : 1531 - 1537
  • [39] NSAIDs causes corneal epithelial damage by inhibition of leukotriene B4 receptor 2 signaling
    Iwamoto, Satoshi
    Koga, Tomoaki
    Okuno, Toshiaki
    Murakami, Akira
    Matsuda, Akira
    Yokomizo, Takehiko
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (12)
  • [40] Urinary metabolites of leukotriene B4 in the human subject
    Berry, KAZ
    Borgeat, P
    Gosselin, J
    Flamand, L
    Murphy, RC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (27) : 24449 - 24460
12345