Role of leukotriene B4 receptor signaling in human preadipocyte differentiation

被引：6
|
作者：
Hirata, Kae [1 ,2 ]
Katayama, Kazufumi [1 ]
Nakajima, Atsushi [3 ]
Takada, Kenji [2 ]
Kamisaki, Yoshinori [1 ]
Wada, Koichiro [1 ]
机构：
[1] Osaka Univ, Grad Sch Dent, Dept Pharmacol, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Dent, Dept Orthodont & Dentofacial Orthoped, Suita, Osaka 5650871, Japan
[3] Yokohama City Univ, Sch Med, Div Gastroenterol, Yokohama, Kanagawa 2360004, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 429卷 / 3-4期
基金：
日本学术振兴会;
关键词：
Leukotriene; Receptor; Adipocyte; Preadipocyte; Differentiation; siRNA; TGFBI; Human; ADENOCARCINOMA CELL-LINE; INSULIN-RESISTANCE; PROLIFERATION; LIPOXIN; BIOSYNTHESIS; BETA-IG-H3; PATHWAY; PROTEIN; OBESITY; GAMMA;
D O I：
10.1016/j.bbrc.2012.10.110
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the role of leukotriene B-4 (LTB4)-leukotriene receptor (BLT) signaling in preadipocyte differentiation into mature adipocytes. Blockade of BLT signaling by treatment with lipoxygenase inhibitors, a BLT antagonist, and small interfering RNAs for BLTs in human and mouse preadipocytes isolated from adipose tissues showed acceleration of differentiation into mature adipocytes. DNA microarray analysis revealed regulation of transforming growth factor, beta-induced 68 kDa (TGFBI) expression through the BLT signaling pathway during adipocyte differentiation. Knockdown of TGFBI also showed acceleration of preadipocyte differentiation. The LTB4-BLT signaling pathway may negatively regulate preadipocyte differentiation via induction of TGFBI expression as a rate-limiting system to control adipocyte differentiation. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：197 / 203
页数：7
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