Synthesis of Some Heterocyclic Molecuoles from New Benzoxazinones and Quinazolinones

被引：0
|
作者：
Soliman, E. A. [1 ]
Shaban, M. E. [1 ]
Guirguis, D. B. [1 ]
Gad, E. S. [1 ]
机构：
[1] Ain Shams Univ, Fac Sci, Chem Dept, Cairo, Egypt
来源：
EGYPTIAN JOURNAL OF CHEMISTRY | 2012年 / 55卷 / 01期
关键词：
Quinazolinones; Benzoxazinones and Schiff's base;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
THE BENZOXAXAZINONE 3 was prepared and treated with hydrazine hydrate, hydroxylamine hydrochloride, and ophenylenediamine to give different quinazolinones 4,5 and benzoimidazoles 6, 7, respectively. Product 4 reacted with different aldehydes forming different Schiff's basses 9,10a - e. Also, it reacted with different Grignard reagents giving alcohols(11a, b) and ketones 11c, d, according to the bulkiness of the reagent. Finally, dibromo, monobromoamino and diaminoquinazolinones (12,13 a-d) & (14 a-d) were prepared upon addition of bromine to 4, followed by reacting different amines according to their molar ratios. Some benzoxazinone, and quinazolinone derivatives were tested for their antifungal and antibacterial activities and gave promising results.
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页码：99 / 110
页数：12
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