Synthesis of Some Heterocyclic Molecuoles from New Benzoxazinones and Quinazolinones

THE BENZOXAXAZINONE 3 was prepared and treated with hydrazine hydrate, hydroxylamine hydrochloride, and ophenylenediamine to give different quinazolinones 4,5 and benzoimidazoles 6, 7, respectively. Product 4 reacted with different aldehydes forming different Schiff's basses 9,10a - e. Also, it reacted with different Grignard reagents giving alcohols(11a, b) and ketones 11c, d, according to the bulkiness of the reagent. Finally, dibromo, monobromoamino and diaminoquinazolinones (12,13 a-d) & (14 a-d) were prepared upon addition of bromine to 4, followed by reacting different amines according to their molar ratios. Some benzoxazinone, and quinazolinone derivatives were tested for their antifungal and antibacterial activities and gave promising results.