REDOX PROPERTIES AND ANTIARRHYTHMIC ACTIVITY OF ALPHA-HEXAMETHYLENE CARBONIC-ACID DERIVATIVES

被引：0
|
作者：
MARINOV, BS [1 ]
BERDJAEV, SY [1 ]
TURILOVA, AI [1 ]
LEBEDEVA, AS [1 ]
LIKHOSHERSTOV, AM [1 ]
机构：
[1] ACAD MED SCI USSR,INST PHARMACOL,MOSCOW 109801,USSR
来源：
BIOLOGICHESKIE MEMBRANY | 1992年 / 9卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Antiarrhythmic activity of alpha-hexamethylene carbonic acid derivatives was assessed using artificial arrhythmias induced in rats. rabbits and guinea pigs. The compounds tested efficiently prevented the aconotine arrhythmia evoked by a modification of Na+ channels. In radical testing reactions they acted as electron donors, similar to other Na+ channel blockers. The electron-donor potency correlated qualitatively with the antiarrhythmic activity of the drugs.
引用
收藏
页码：312 / 318
页数：7
相关论文
共 50 条
  • [31] ABOUT REACTION OF C(NME2)4 WITH SOME DERIVATIVES OF CARBONIC-ACID
    PETZ, W
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 1976, 31 (07): : 1007 - 1008
  • [32] The study of structure-antiarrhythmic activity relationship of N-phenylacetamide derivatives and aromatic carbonic acid amides
    Khairullina V.R.
    Tarasov G.P.
    Gerchikov A.Ya.
    Zarydiy F.S.
    Tyurina L.A.
    Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2010, 4 (2) : 130 - 137
  • [33] REACTIONS OF CYCLIC CARBONIC-ACID ANHYDRIDES WITH (ALPHA,ALPHA-'-DIPYRIDYL)-(CYCLOOCTADIENE-1,5) NICKEL
    UHLIG, E
    FEHSKE, G
    NESTLER, B
    ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 1980, 465 (06): : 141 - 146
  • [34] ACYLATION OF N-(2,6-DIMETHYLPHENYL)-ALPHA-ALANINE METHYLESTER WITH SP-HYBRIDIZED CARBONIC-ACID DERIVATIVES
    MARTIN, D
    JOURNAL FUR PRAKTISCHE CHEMIE, 1991, 333 (02): : 261 - 266
  • [35] NUCLEOPHILIC SUBSTITUTIONS AT CARBONIC-ACID DERIVATIVES .19. ALCOHOLYSIS AND HYDROLYSIS OF BIS(TRICHLOROMETHYL)CARBONATE
    COTARCA, L
    BACALOGLU, R
    MARCU, N
    TARNAVEANU, A
    JOURNAL FUR PRAKTISCHE CHEMIE, 1985, 327 (06): : 881 - 886
  • [36] ACYLATION OF HYDROXYL-GROUPS IN POLYMERS WITH CARBONIC-ACID DERIVATIVES IN THE PRESENCE OF TERTIARY-AMINES
    BOEDEN, HF
    BUTTNER, W
    RUPPRICH, C
    BUTTNER, D
    HEINRICH, S
    BECKER, M
    HOLTZHAUER, M
    MAKROMOLEKULARE CHEMIE-MACROMOLECULAR CHEMISTRY AND PHYSICS, 1992, 193 (04): : 865 - 887
  • [37] EFFECT OF CARBONIC-ACID GAS HIGHER CONCENTRATIONS ON MALT HYDROLAZE ACTIVITY WHEN GERMINATING
    BALENKO, TL
    DOMARETSKY, VA
    VELIKAYA, EI
    IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII PISHCHEVAYA TEKHNOLOGIYA, 1980, (01): : 28 - 30
  • [38] ANTIARRHYTHMIC PROPERTIES OF DIBASIC ALKOXYSUBSTITUTED DERIVATIVES OF CARBANILIC ACID
    SVEC, P
    BEDEROVA, E
    TUMOVA, I
    LAPINSKAS, L
    JOURNAL DE PHARMACOLOGIE, 1986, 17 (02) : 209 - 209
  • [39] Antiarrhythmic properties of some aroxyethylamine derivatives with adrenolytic activity
    Maciag, D.
    Bednarski, M.
    Filipek, B.
    Pociecha, T.
    Szkaradek, N.
    Marona, H.
    PHARMAZIE, 2008, 63 (06): : 480 - 484
  • [40] EFFECT OF CARBONIC-ACID CONCENTRATION IN BLOOD ON CONTENT OF KETO-ACIDS AND REDOX STATE OF NICOTINAMIDE COENZYMES IN RABBIT TISSUES
    MELNYCHUK, DO
    SKORYK, LV
    SCHOLZ, C
    MITSYK, EV
    GULY, MF
    UKRAINSKII BIOKHIMICHESKII ZHURNAL, 1977, 49 (05): : 86 - 93
12345