REDOX PROPERTIES AND ANTIARRHYTHMIC ACTIVITY OF ALPHA-HEXAMETHYLENE CARBONIC-ACID DERIVATIVES

被引：0
|
作者：
MARINOV, BS [1 ]
BERDJAEV, SY [1 ]
TURILOVA, AI [1 ]
LEBEDEVA, AS [1 ]
LIKHOSHERSTOV, AM [1 ]
机构：
[1] ACAD MED SCI USSR,INST PHARMACOL,MOSCOW 109801,USSR
来源：
BIOLOGICHESKIE MEMBRANY | 1992年 / 9卷 / 03期
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D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Antiarrhythmic activity of alpha-hexamethylene carbonic acid derivatives was assessed using artificial arrhythmias induced in rats. rabbits and guinea pigs. The compounds tested efficiently prevented the aconotine arrhythmia evoked by a modification of Na+ channels. In radical testing reactions they acted as electron donors, similar to other Na+ channel blockers. The electron-donor potency correlated qualitatively with the antiarrhythmic activity of the drugs.
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页码：312 / 318
页数：7
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