REDOX PROPERTIES AND ANTIARRHYTHMIC ACTIVITY OF ALPHA-HEXAMETHYLENE CARBONIC-ACID DERIVATIVES

被引：0

作者：

MARINOV, BS ^{[1
]}

BERDJAEV, SY ^{[1
]}

TURILOVA, AI ^{[1
]}

LEBEDEVA, AS ^{[1
]}

LIKHOSHERSTOV, AM ^{[1
]}

机构：

[1] ACAD MED SCI USSR,INST PHARMACOL,MOSCOW 109801,USSR

来源：

BIOLOGICHESKIE MEMBRANY | 1992年 / 9卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Antiarrhythmic activity of alpha-hexamethylene carbonic acid derivatives was assessed using artificial arrhythmias induced in rats. rabbits and guinea pigs. The compounds tested efficiently prevented the aconotine arrhythmia evoked by a modification of Na+ channels. In radical testing reactions they acted as electron donors, similar to other Na+ channel blockers. The electron-donor potency correlated qualitatively with the antiarrhythmic activity of the drugs.

引用

页码：312 / 318

页数：7

共 50 条

[1] REACTIVE MONOMERIC CARBONIC-ACID DERIVATIVES
KUHLE, E
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1973, 12 (08): : 630 - 643
[2] PREPARATION AND REACTIONS OF CHLORODISULFANYL DERIVATIVES OF CARBONIC-ACID
BOHME, H
BRINKMANN, M
STEUDEL, HP
LIEBIGS ANNALEN DER CHEMIE, 1981, (07): : 1244 - 1251
[3] PHOTOREACTIVITY OF CARBONIC-ACID DERIVATIVES IN A REDUCTIVE ENVIRONMENT
DEMBELE, YA
DESHAYES, H
PETE, JP
TETRAHEDRON LETTERS, 1982, 23 (34) : 3489 - 3492
[4] QUANTUM CHEMICAL CONTRIBUTIONS TO THE CHEMISTRY OF CARBONIC-ACID DERIVATIVES
SCHADLER, HD
ZEITSCHRIFT FUR CHEMIE, 1988, 28 (08): : 278 - 284
[5] HYDROLASE-MEDIATED RESOLUTIONS WITH CARBONIC-ACID DERIVATIVES
MARTIN, AA
BIOCATALYSIS, 1994, 10 (1-4): : 257 - 267
[6] REDUCTION AND PHOTOREDUCTION OF CARBONIC-ACID DERIVATIVES, EFFECT OF HEXAMETHYLPHOSPHOROTRIAMIDE
DEMBELE, A
DESHAYES, H
PETE, JP
BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1988, (04): : 671 - 680
[7] NUCLEOPHILIC SUBSTITUTIONS ON CARBONIC-ACID DERIVATIVES .5. KINETICS AND MECHANISM OF ETHANOLYSIS OF ARYL ESTERS OF CARBONIC-ACID CHLORIDES
CSUNDERLIK, C
BACALOGLU, R
OSTROGOVICH, G
JOURNAL FUR PRAKTISCHE CHEMIE, 1975, 317 (01): : 81 - 85
[8] ACYLATION OF HETEROCYCLES WITH CARBONIC-ACID DERIVATIVES .3.
MARTIN, D
TITTELBACH, F
TETRAHEDRON, 1983, 39 (13) : 2311 - 2314
[9] NUCLEOPHILIC SUBSTITUTIONS ON CARBONIC-ACID DERIVATIVES .3. KINETICS AND MECHANISM OF HYDROLYSIS OF ARYL ESTERS OF CARBONIC-ACID CHLORIDES
OSTROGOVICH, G
CSUNDERLIK, C
BACALOGLU, R
JOURNAL FUR PRAKTISCHE CHEMIE, 1975, 317 (01): : 62 - 72
[10] CHALCOGENOLATES .63. STUDIES ON HEMIESTERS OF CARBONIC-ACID .2. PREPARATION AND PROPERTIES OF MONOMETHYL CARBONIC-ACID
BEHRENDT, W
GATTOW, G
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 1973, 398 (02): : 198 - 206

← 1 2 3 4 5 →