MULTICENTER PHASE-II TRIAL OF BREQUINAR SODIUM IN PATIENTS WITH ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK

被引：38
|
作者：
URBA, S
DOROSHOW, J
CRIPPS, C
ROBERT, F
VELEZGARCIA, E
DALLAIRE, B
ADAMS, D
CARLSON, R
GRILLOLOPEZ, A
GYVES, J
机构：
[1] CITY HOPE NATL MED CTR,DUARTE,CA 91010
[2] OTTAWA REG CANC CTR,OTTAWA,ONTARIO,CANADA
[3] SAN JUAN VET HOSP,SAN JUAN,PR
[4] DUPONT PHARMACEUT CO,WILMINGTON,DE
[5] UNIV PUERTO RICO,SCH MED,SAN JUAN,PR 00936
[6] UNIV MICHIGAN,ANN ARBOR,MI 48109
来源：
CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1992年 / 31卷 / 02期
关键词：
D O I：
10.1007/BF00685106
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A total of 19 patients with advanced squamous-cell carcinoma of the head and neck who had not previously been exposed to chemotherapy were treated with brequinar sodium as first-line chemotherapy. Brequinar was given intravenously at a median weekly dose of 1,200 mg/m2. The toxicity was moderate, with 7 patients (37%) experiencing grade 3 or 4 toxicity. In all, 16 patients who were evaluable for efficacy showed no objective response. We conclude that brequinar given at this dose and on this schedule has no significant activity in advanced squamous-cell carcinoma of the head and neck.
引用
收藏
页码：167 / 169
页数：3
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