MULTICENTER PHASE-II TRIAL OF BREQUINAR SODIUM IN PATIENTS WITH ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK

被引：38
|
作者：
URBA, S
DOROSHOW, J
CRIPPS, C
ROBERT, F
VELEZGARCIA, E
DALLAIRE, B
ADAMS, D
CARLSON, R
GRILLOLOPEZ, A
GYVES, J
机构：
[1] CITY HOPE NATL MED CTR,DUARTE,CA 91010
[2] OTTAWA REG CANC CTR,OTTAWA,ONTARIO,CANADA
[3] SAN JUAN VET HOSP,SAN JUAN,PR
[4] DUPONT PHARMACEUT CO,WILMINGTON,DE
[5] UNIV PUERTO RICO,SCH MED,SAN JUAN,PR 00936
[6] UNIV MICHIGAN,ANN ARBOR,MI 48109
来源：
CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1992年 / 31卷 / 02期
关键词：
D O I：
10.1007/BF00685106
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A total of 19 patients with advanced squamous-cell carcinoma of the head and neck who had not previously been exposed to chemotherapy were treated with brequinar sodium as first-line chemotherapy. Brequinar was given intravenously at a median weekly dose of 1,200 mg/m2. The toxicity was moderate, with 7 patients (37%) experiencing grade 3 or 4 toxicity. In all, 16 patients who were evaluable for efficacy showed no objective response. We conclude that brequinar given at this dose and on this schedule has no significant activity in advanced squamous-cell carcinoma of the head and neck.
引用
收藏
页码：167 / 169
页数：3
相关论文
共 50 条
  • [31] A PHASE-II TRIAL OF DEOXYSPERGUALIN IN RECURRENT SQUAMOUS-CELL HEAD AND NECK-CANCER
    PFISTER, DG
    BAJORIN, D
    MOTZER, RJ
    SCHER, H
    LOUISON, C
    HARRISON, L
    SHAH, J
    STRONG, E
    BOSL, G
    INVESTIGATIONAL NEW DRUGS, 1993, 11 (01) : 53 - 56
  • [32] A PHASE-II STUDY OF ADRIAMYCIN IN PREVIOUSLY UNTREATED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    COBLEIGH, MA
    HILL, JH
    GALLAGHER, PA
    KUKLA, LJ
    LAD, TE
    SHEVRIN, DH
    APPLEBAUM, EL
    MCGUIRE, WP
    CANCER, 1985, 56 (11) : 2573 - 2575
  • [33] PHASE-II STUDY OF ETOPOSIDE IN PREVIOUSLY UNTREATED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    COBLEIGH, MA
    HILL, JH
    LAD, TE
    SHEVRIN, DE
    APPLEBAUM, EL
    CANCER TREATMENT REPORTS, 1987, 71 (03): : 321 - 322
  • [34] CISPLATIN AND IFOSFAMIDE IN PATIENTS WITH ADVANCED SQUAMOUS-CELL CARCINOMA OF THE UTERINE CERVIX - A PHASE-II TRIAL
    CERVELLINO, JC
    ARAUJO, CE
    SANCHEZ, O
    MILES, H
    NISHIHAMA, A
    ACTA ONCOLOGICA, 1995, 34 (02) : 257 - 259
  • [35] PHASE-II STUDY OF IPROPLATIN (CHIP, JM-9) IN ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    ABELE, R
    CLAVEL, M
    MONFARDINI, S
    BRUNTSCH, U
    RENARD, J
    VANGLABBEKE, M
    PINEDO, HM
    EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1987, 23 (04): : 387 - 389
  • [36] PHASE-II TRIAL OF PIROXANTRONE IN PATIENTS WITH RECURRENT AND METASTATIC SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK - A SOUTHWEST-ONCOLOGY-GROUP TRIAL
    TAYLOR, SA
    BENEDETTI, J
    SCHULLER, D
    RICHMAN, SP
    BROUN, GO
    HANTEL, A
    INVESTIGATIONAL NEW DRUGS, 1993, 11 (2-3) : 227 - 229
  • [37] A PHASE-II TRIAL OF CYCLOPHOSPHAMIDE AND ADRIAMYCIN IN REFRACTORY SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK - AN EFFECTIVE SALVAGE REGIMEN
    BITRAN, JD
    GOLDMAN, M
    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1985, 8 (01): : 61 - 64
  • [38] PHASE-II TRIAL OF WEEKLY 4-EPI-DOXORUBICIN (EPIRUBICIN) IN SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    BERTETTO, O
    DONGIOVANNI, V
    CLERICO, M
    CALCIATI, A
    TUMORI, 1987, 73 (01) : 65 - 67
  • [39] A PHASE-II TRIAL OF 10-ETHYL-10-DEAZA-AMINOPTERIN, A NOVEL ANTIFOLATE, IN PATIENTS WITH ADVANCED AND OR RECURRENT SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
    SCHORNAGEL, JH
    VERWEIJ, J
    DEMULDER, PHM
    COGNETTI, F
    VERMORKEN, JB
    CAPPELAERE, P
    ARMAND, JP
    WILDIERS, J
    CLAVEL, M
    KIRKPATRICK, A
    LEFEBVRE, JL
    ANNALS OF ONCOLOGY, 1992, 3 (03) : 223 - 226
  • [40] MULTICENTER PHASE-II STUDY OF BREQUINAR SODIUM IN PATIENTS WITH ADVANCED LUNG-CANCER
    MAROUN, J
    RUCKDESCHEL, J
    NATALE, R
    MORGAN, R
    DALLAIRE, B
    SISK, R
    GYVES, J
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1993, 32 (01) : 64 - 66
12345