MULTICENTER PHASE-II TRIAL OF BREQUINAR SODIUM IN PATIENTS WITH ADVANCED SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK

被引：38

作者：

URBA, S

DOROSHOW, J

CRIPPS, C

ROBERT, F

VELEZGARCIA, E

DALLAIRE, B

ADAMS, D

CARLSON, R

GRILLOLOPEZ, A

GYVES, J

机构：

[1] CITY HOPE NATL MED CTR,DUARTE,CA 91010

[2] OTTAWA REG CANC CTR,OTTAWA,ONTARIO,CANADA

[3] SAN JUAN VET HOSP,SAN JUAN,PR

[4] DUPONT PHARMACEUT CO,WILMINGTON,DE

[5] UNIV PUERTO RICO,SCH MED,SAN JUAN,PR 00936

[6] UNIV MICHIGAN,ANN ARBOR,MI 48109

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1992年 / 31卷 / 02期

关键词：

D O I：

10.1007/BF00685106

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A total of 19 patients with advanced squamous-cell carcinoma of the head and neck who had not previously been exposed to chemotherapy were treated with brequinar sodium as first-line chemotherapy. Brequinar was given intravenously at a median weekly dose of 1,200 mg/m2. The toxicity was moderate, with 7 patients (37%) experiencing grade 3 or 4 toxicity. In all, 16 patients who were evaluable for efficacy showed no objective response. We conclude that brequinar given at this dose and on this schedule has no significant activity in advanced squamous-cell carcinoma of the head and neck.

引用

页码：167 / 169

页数：3

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