DECREASED ACTIVITY OF LIVER COPROPORPHYRINOGEN OXIDASE IN HEXACHLOROBENZENE-INDUCED PORPHYRIA

被引：0
|
作者：
ADJAROV, DG [1 ]
机构：
[1] UNIV COLL CARDIFF,DEPT MED BIOCHEM,CARDIFF CF4 4XN,S GLAM,WALES
来源：
EXPERIMENTAL PATHOLOGY | 1990年 / 40卷 / 02期
基金：
英国惠康基金;
关键词：
coproporphyrinogen oxidase; hepatic coproporphyrinogen oxidase; hexachlorobenzene; liver coproporphyrinogen oxidase; porphyria;
D O I：
10.1016/S0232-1513(11)80331-2
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
A 2.5-time decrease of hepatic coprophorphyrinogen oxidase activity was established in mice fed for 8 weeks with a diet containing 0.02% hexachlorobenzene. The enzyme activity was determined by a newly developed technique measuring directly the unconverted substrate, coproporphyrinogen III, with reverse phase HPLC (high-performance liquid chromatography) after its spontaneous oxidation to coproporphyria. © 1990, Gustav Fischer Verlag Jena. All rights reserved.
引用
收藏
页码：117 / 122
页数：6
相关论文
共 50 条
  • [41] HEXACHLOROBENZENE-INDUCED PORPHYRIA IN JAPANESE-QUAIL - AN INVITRO STUDY OF CHANGES IN CYTOCHROME-P-450 AND MONOOXYGENASES
    CARPENTER, HM
    WILLIAMS, DE
    BUHLER, DR
    JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1985, 16 (02): : 207 - 217
  • [42] HEPATIC IRON STORES SUGGEST INCREASED DIETARY IRON-ABSORPTION IN EXPERIMENTAL HEXACHLOROBENZENE-INDUCED RAT PORPHYRIA
    FELDMAN, ES
    BRITTENHAM, GM
    HEPATOLOGY, 1985, 5 (05) : 1013 - 1013
  • [43] HEXACHLOROBENZENE INDUCED EXPERIMENTAL PORPHYRIA
    DESALAMANCA, RE
    DESALAMANCA, CE
    SEMINARS IN DERMATOLOGY, 1986, 5 (02): : 206 - 212
  • [44] Heme metabolism and lipid peroxidation in rat kidney hexachlorobenzene-induced porphyria:: A compartmentalized study of biochemical pathogenic mechanisms
    Fernández-Tomé, MD
    de Catabbi, SCB
    Aldonatti, C
    de Viale, LCS
    Sterin-Speziale, NB
    KIDNEY & BLOOD PRESSURE RESEARCH, 2000, 23 (01): : 20 - 26
  • [45] STUDIES ON THE ETIOLOGY OF TRACE METAL-INDUCED PORPHYRIA - EFFECTS OF PORPHYRINOGENIC METALS ON COPROPORPHYRINOGEN OXIDASE IN RAT-LIVER AND KIDNEY
    WOODS, JS
    SOUTHERN, MR
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1989, 97 (01) : 183 - 190
  • [46] ENZYMIC AND ELECTROPHORETIC CHARACTERIZATION OF THE HEXACHLOROBENZENE-INDUCED CYTOCHROME-P-450 IN THE LIVER OF RAT
    VIZETHUM, W
    BURKHARDT, F
    GOERZ, G
    XENOBIOTICA, 1980, 10 (02) : 145 - 150
  • [47] BILE AND BILIARY LIPID SECRETION IN RATS WITH HEXACHLOROBENZENE-INDUCED PORPHYRIA - EFFECT OF S-ADENOSYL-L-METHIONINE ADMINISTRATION
    CUOMO, R
    RODINO, S
    RIZZOLI, R
    SIMONI, P
    RODA, E
    CANTONI, L
    RIZZARDINI, M
    DEROSA, G
    LEGRAZIE, C
    DIPADOVA, C
    BUDILLON, G
    JOURNAL OF HEPATOLOGY, 1991, 12 (01) : 87 - 93
  • [48] EFFECT OF LIGHT UPON PORPHYRIN METABOLISM OF RATS - STUDY OF PORPHYRIN METABOLISM OF NORMAL RATS + RATS WITH HEXACHLOROBENZENE-INDUCED PORPHYRIA
    BURNETT, JW
    PATHAK, MA
    ARCHIVES OF DERMATOLOGY, 1964, 89 (02) : 257 - &
  • [49] Macrophages are involved in hexachlorobenzene-induced adverse immune effects
    Ezendam, J
    Kosterman, K
    Spijkerboer, H
    Bleumink, R
    Hassing, I
    van Rooijen, N
    Vos, JG
    Pieters, R
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2005, 209 (01) : 19 - 27
  • [50] INFLUENCE OF THEOPHYLLINE ON HEXACHLOROBENZENE INDUCED PORPHYRIA
    GOERZ, G
    BOLSEN, K
    STAIB, AH
    LISSNER, R
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1981, 31-2 (09): : 1446 - 1447
12345