DECREASED ACTIVITY OF LIVER COPROPORPHYRINOGEN OXIDASE IN HEXACHLOROBENZENE-INDUCED PORPHYRIA

被引：0
|
作者：
ADJAROV, DG [1 ]
机构：
[1] UNIV COLL CARDIFF,DEPT MED BIOCHEM,CARDIFF CF4 4XN,S GLAM,WALES
来源：
EXPERIMENTAL PATHOLOGY | 1990年 / 40卷 / 02期
基金：
英国惠康基金;
关键词：
coproporphyrinogen oxidase; hepatic coproporphyrinogen oxidase; hexachlorobenzene; liver coproporphyrinogen oxidase; porphyria;
D O I：
10.1016/S0232-1513(11)80331-2
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
A 2.5-time decrease of hepatic coprophorphyrinogen oxidase activity was established in mice fed for 8 weeks with a diet containing 0.02% hexachlorobenzene. The enzyme activity was determined by a newly developed technique measuring directly the unconverted substrate, coproporphyrinogen III, with reverse phase HPLC (high-performance liquid chromatography) after its spontaneous oxidation to coproporphyria. © 1990, Gustav Fischer Verlag Jena. All rights reserved.
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页码：117 / 122
页数：6
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