DECREASED ACTIVITY OF LIVER COPROPORPHYRINOGEN OXIDASE IN HEXACHLOROBENZENE-INDUCED PORPHYRIA

被引:0
|
作者
ADJAROV, DG [1 ]
机构
[1] UNIV COLL CARDIFF,DEPT MED BIOCHEM,CARDIFF CF4 4XN,S GLAM,WALES
来源
EXPERIMENTAL PATHOLOGY | 1990年 / 40卷 / 02期
基金
英国惠康基金;
关键词
coproporphyrinogen oxidase; hepatic coproporphyrinogen oxidase; hexachlorobenzene; liver coproporphyrinogen oxidase; porphyria;
D O I
10.1016/S0232-1513(11)80331-2
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
A 2.5-time decrease of hepatic coprophorphyrinogen oxidase activity was established in mice fed for 8 weeks with a diet containing 0.02% hexachlorobenzene. The enzyme activity was determined by a newly developed technique measuring directly the unconverted substrate, coproporphyrinogen III, with reverse phase HPLC (high-performance liquid chromatography) after its spontaneous oxidation to coproporphyria. © 1990, Gustav Fischer Verlag Jena. All rights reserved.
引用
收藏
页码:117 / 122
页数:6
相关论文
共 50 条
  • [21] HEXACHLOROBENZENE-INDUCED PORPHYRIA - EFFECT OF CHELATION ON DISEASE PORPHYRIN AND METAL METABOLISM
    PETERS, HA
    JOHNSON, SAM
    CAM, S
    ORAL, S
    MUFFTU, Y
    ERGENE, T
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1966, 251 (03): : 314 - +
  • [22] MODULATION OF HEXACHLOROBENZENE-INDUCED HEPATIC PORPHYRIA BY METHYL ISOBUTYL KETONE IN THE RAT
    KRISHNAN, K
    BRODEUR, J
    PLAA, GL
    CHARBONNEAU, M
    TOXICOLOGY LETTERS, 1992, 61 (2-3) : 167 - 174
  • [23] THE INVOLVEMENT OF IRON AND LIPID-PEROXIDATION IN THE PATHOGENESIS OF HEXACHLOROBENZENE-INDUCED PORPHYRIA
    ALLEMAN, MA
    KOSTER, JF
    WILSON, JHP
    EDIXHOVEN, A
    SLEE, RG
    KROES, MJ
    VANEIJK, HG
    HEPATOLOGY, 1984, 4 (04) : 774 - 774
  • [24] IRON-ABSORPTION DURING THE DEVELOPMENT OF HEXACHLOROBENZENE-INDUCED PORPHYRIA IN RATS
    SCHAFER, SG
    RICHTER, E
    MEYER, HD
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 1982, 274 (3-4) : 349 - 357
  • [25] REDUCED SERUM THYROID-HORMONE LEVELS IN HEXACHLOROBENZENE-INDUCED PORPHYRIA
    ROZMAN, K
    GORSKI, JR
    ROZMAN, P
    PARKINSON, A
    TOXICOLOGY LETTERS, 1986, 30 (01) : 71 - 78
  • [26] INFLUENCE OF HEPATIC-TUMORS CAUSED BY DIETHYLNITROSAMINE ON HEXACHLOROBENZENE-INDUCED PORPHYRIA IN RATS
    DECALMANOVICI, RW
    COCHON, AC
    ZENKLUSEN, JC
    ALDONATTI, C
    CABRAL, JRP
    DEVIALE, LCS
    CANCER LETTERS, 1991, 58 (03) : 225 - 232
  • [27] DEVELOPMENT OF AN EXPERIMENTAL-MODEL FOR THE STUDY OF HEXACHLOROBENZENE-INDUCED HEPATIC PORPHYRIA IN THE RAT
    KRISHNAN, K
    BRODEUR, J
    CHARBONNEAU, M
    FUNDAMENTAL AND APPLIED TOXICOLOGY, 1991, 17 (03): : 433 - 441
  • [28] Studies on the mechanism of uroporphyrinogen decarboxylase inhibition in hexachlorobenzene-induced porphyria in the female rat
    Mylchreest, E
    Charbonneau, M
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1997, 145 (01) : 23 - 33
  • [29] INVESTIGATIONS ON THE ROLE OF FREE-RADICAL PROCESSES IN HEXACHLOROBENZENE-INDUCED PORPHYRIA IN MICE
    RIZZARDINI, M
    GRAZIANI, A
    CARUGO, C
    CANTONI, L
    JOURNAL OF BIOCHEMICAL TOXICOLOGY, 1988, 3 : 33 - 45
  • [30] Abnormal kinetic behavior of uroporphyrinogen decarboxylase obtained from rats with hexachlorobenzene-induced porphyria
    Chaufan, G
    Corvi, MM
    de Viale, LCS
    Cárdenas, ML
    de Molina, MDC
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2005, 19 (01) : 19 - 24