DECREASED ACTIVITY OF LIVER COPROPORPHYRINOGEN OXIDASE IN HEXACHLOROBENZENE-INDUCED PORPHYRIA

被引：0
|
作者：
ADJAROV, DG [1 ]
机构：
[1] UNIV COLL CARDIFF,DEPT MED BIOCHEM,CARDIFF CF4 4XN,S GLAM,WALES
来源：
EXPERIMENTAL PATHOLOGY | 1990年 / 40卷 / 02期
基金：
英国惠康基金;
关键词：
coproporphyrinogen oxidase; hepatic coproporphyrinogen oxidase; hexachlorobenzene; liver coproporphyrinogen oxidase; porphyria;
D O I：
10.1016/S0232-1513(11)80331-2
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
A 2.5-time decrease of hepatic coprophorphyrinogen oxidase activity was established in mice fed for 8 weeks with a diet containing 0.02% hexachlorobenzene. The enzyme activity was determined by a newly developed technique measuring directly the unconverted substrate, coproporphyrinogen III, with reverse phase HPLC (high-performance liquid chromatography) after its spontaneous oxidation to coproporphyria. © 1990, Gustav Fischer Verlag Jena. All rights reserved.
引用
收藏
页码：117 / 122
页数：6
相关论文
共 50 条
  • [1] Stimulation of liver heme oxygenase in hexachlorobenzene-induced hepatic porphyria
    Michael D. Stonard
    Giuseppe Poli
    Francesco De Matteis
    Archives of Toxicology, 1998, 72 : 355 - 361
  • [2] Stimulation of liver heme oxygenase in hexachlorobenzene-induced hepatic porphyria
    Stonard, MD
    Poli, G
    De Matteis, F
    ARCHIVES OF TOXICOLOGY, 1998, 72 (06) : 355 - 361
  • [3] HEPATIC GSH IN HEXACHLOROBENZENE-INDUCED PORPHYRIA
    WOLF, MA
    LESTER, R
    SCHMID, R
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1962, 8 (04) : 278 - &
  • [4] INFLUENCE OF CHLOROQUINE ON THE HEXACHLOROBENZENE-INDUCED PORPHYRIA - INVESTIGATIONS IN THE SKIN, LIVER, AND URINE
    VIZETHUM, W
    BOLSEN, K
    SIMON, K
    WEBER, K
    GOERZ, G
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 1980, 267 (02) : 123 - 130
  • [5] INFLUENCE OF (+)-PROPOXYPHENE ON THE HEXACHLOROBENZENE-INDUCED PORPHYRIA OF RATS
    MERK, H
    VONZITTWITZ, A
    BOLSEN, K
    GOERZ, G
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1985, 35-2 (11): : 1685 - 1687
  • [6] EFFECT OF DESFERRIOXAMINE ON THE DEVELOPMENT OF HEXACHLOROBENZENE-INDUCED PORPHYRIA
    DECALMANOVICI, RW
    BILLI, SC
    ALDONATTI, CA
    DEVIALE, LCSM
    BIOCHEMICAL PHARMACOLOGY, 1986, 35 (14) : 2399 - 2405
  • [7] DOSE-RESPONSE RELATIONSHIPS IN HEXACHLOROBENZENE-INDUCED PORPHYRIA
    KENNEDY, SW
    WIGFIELD, DC
    BIOCHEMICAL PHARMACOLOGY, 1990, 40 (06) : 1381 - 1388
  • [8] ORIGIN OF URINARY PORPHYRINS IN EXPERIMENTAL HEXACHLOROBENZENE-INDUCED PORPHYRIA
    ADJAROV, D
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1990, 109 (04) : 463 - 465
  • [9] STUDIES ON THE ROLE OF THE AH RECEPTOR IN HEXACHLOROBENZENE-INDUCED PORPHYRIA
    HAHN, ME
    GASIEWICZ, TA
    LINKO, P
    GOLDSTEIN, JA
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 514 : 333 - 334
  • [10] HEXACHLOROBENZENE-INDUCED TURKISH PORPHYRIA - A 30 YEAR STUDY
    PETERS, HA
    CRIPPS, D
    BRYAN, T
    GOCMEN, A
    MOLECULAR ASPECTS OF MEDICINE, 1990, 11 (1-2) : 11 - 12
12345