PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDES (PACAPS) INCREASE CAMP IN RAT CEREBRAL MICROVESSELS

被引：15
|
作者：
KOBAYASHI, H
UEZONO, Y
UENO, S
IZUMI, F
机构：
[1] Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi-ku, Kitakyushu, 807
来源：
BRAIN RESEARCH | 1994年 / 647卷 / 01期
关键词：
PACAP; CEREBRAL MICROVESSEL; CAMP; PEPTIDE;
D O I：
10.1016/0006-8993(94)91409-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Effect of PACAP on cAMP level in the rat cerebral microvessels was investigated. The cerebral microvessels were prepared from rat cerebral cortex by albumin flotation and glass beads filtration technique. When the microvessels were incubated with PACAP 27, PACAP 38 and VIP, cAMP in the microvessels was increased rapidly reaching a plateau value within 60 s. PACAP 27, PACAP 38 and VIP increased cAMP level in a dose-dependent manner with EC(50) values of 4.7, 7.0 and 34 nM, respectively. These results suggest that PACAPs play a role in the regulation of the cerebral microvessel function.
引用
收藏
页码：145 / 147
页数：3
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