PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDES (PACAPS) INCREASE CAMP IN RAT CEREBRAL MICROVESSELS

被引：15
|
作者：
KOBAYASHI, H
UEZONO, Y
UENO, S
IZUMI, F
机构：
[1] Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi-ku, Kitakyushu, 807
来源：
BRAIN RESEARCH | 1994年 / 647卷 / 01期
关键词：
PACAP; CEREBRAL MICROVESSEL; CAMP; PEPTIDE;
D O I：
10.1016/0006-8993(94)91409-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Effect of PACAP on cAMP level in the rat cerebral microvessels was investigated. The cerebral microvessels were prepared from rat cerebral cortex by albumin flotation and glass beads filtration technique. When the microvessels were incubated with PACAP 27, PACAP 38 and VIP, cAMP in the microvessels was increased rapidly reaching a plateau value within 60 s. PACAP 27, PACAP 38 and VIP increased cAMP level in a dose-dependent manner with EC(50) values of 4.7, 7.0 and 34 nM, respectively. These results suggest that PACAPs play a role in the regulation of the cerebral microvessel function.
引用
收藏
页码：145 / 147
页数：3
相关论文
共 50 条
  • [31] Targeted Pituitary Adenylate Cyclase-Activating Peptide Therapies for Migraine
    Anne Luise Haulund Vollesen
    Faisal Mohammad Amin
    Messoud Ashina
    Neurotherapeutics, 2018, 15 : 371 - 376
  • [32] PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AS A NEUROTRANSMITTER IN RAT ADRENAL-MEDULLA
    WAKADE, AR
    GUO, X
    STRONG, R
    ARIMURA, A
    HAYCOCK, J
    REGULATORY PEPTIDES, 1992, 37 (03) : 331 - 331
  • [33] INVOLVEMENT OF THE PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE IN EXCESSIVE DRINKING
    Minnig, M. A.
    Sabino, V.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2019, 43 : 154A - 154A
  • [34] Localization and gene expression of the receptor for pituitary adenylate cyclase-activating polypeptide in the rat brain
    Shioda, S
    Shuto, Y
    SomogyvariVigh, A
    Legradi, G
    Onda, H
    Coy, DH
    Nakajo, S
    Arimura, A
    NEUROSCIENCE RESEARCH, 1997, 28 (04) : 345 - 354
  • [35] Pituitary adenylate cyclase-activating polypeptide activates KATP current in rat atrial myocytes
    Baron, A
    Monnier, D
    Roatti, A
    Baertschi, AJ
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 280 (03): : H1058 - H1065
  • [36] Role of Pituitary Adenylate Cyclase-Activating Polypeptide in Nociception and Migraine
    Tajti, Janos
    Tuka, Bernadett
    Botz, Balint
    Helyes, Zsuzsanna
    Vecsei, Laszlo
    CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2015, 14 (04) : 540 - 553
  • [37] RECEPTORS FOR PITUITARY ADENYLATE CYCLASE-ACTIVATING PEPTIDE IN HUMAN LIVER
    GUIJARRO, LG
    RODRIGUEZHENCHE, N
    GARCIALOPEZ, E
    NOGUERALES, F
    DAPENA, MA
    JUARRANZ, MG
    PRIETO, JC
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (08): : 2451 - 2457
  • [38] Effect of Pituitary Adenylate Cyclase-Activating Polypeptide in Islet Transplantation
    Sakuma, Y.
    Ricordi, C.
    Miki, A.
    Yamamoto, T.
    Mita, A.
    Barker, S.
    Damaris, R. M.
    Pileggi, A.
    Yasuda, Y.
    Yada, T.
    Ichii, H.
    TRANSPLANTATION PROCEEDINGS, 2009, 41 (01) : 343 - 345
  • [39] Pituitary adenylate cyclase-activating polypeptide, effects in the human nose
    Kinhult, J
    Adner, M
    Uddman, R
    Cardell, LO
    CLINICAL AND EXPERIMENTAL ALLERGY, 2003, 33 (07): : 942 - 949
  • [40] Pituitary adenylate cyclase-activating polypeptide (PACAP) and islet function
    Ahren, Bo
    REGULATORY PEPTIDES, 2010, 164 (01) : 23 - 23
12345