PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDES (PACAPS) INCREASE CAMP IN RAT CEREBRAL MICROVESSELS

被引：15
|
作者：
KOBAYASHI, H
UEZONO, Y
UENO, S
IZUMI, F
机构：
[1] Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi-ku, Kitakyushu, 807
来源：
BRAIN RESEARCH | 1994年 / 647卷 / 01期
关键词：
PACAP; CEREBRAL MICROVESSEL; CAMP; PEPTIDE;
D O I：
10.1016/0006-8993(94)91409-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Effect of PACAP on cAMP level in the rat cerebral microvessels was investigated. The cerebral microvessels were prepared from rat cerebral cortex by albumin flotation and glass beads filtration technique. When the microvessels were incubated with PACAP 27, PACAP 38 and VIP, cAMP in the microvessels was increased rapidly reaching a plateau value within 60 s. PACAP 27, PACAP 38 and VIP increased cAMP level in a dose-dependent manner with EC(50) values of 4.7, 7.0 and 34 nM, respectively. These results suggest that PACAPs play a role in the regulation of the cerebral microvessel function.
引用
收藏
页码：145 / 147
页数：3
相关论文
共 50 条
  • [21] Pituitary Adenylate Cyclase-Activating Polypeptide in Learning and Memory
    Gilmartin, Marieke R.
    Ferrara, Nicole C.
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2021, 15
  • [22] Pituitary adenylate cyclase-activating polypeptide in intrinsic and extrinsic nerves of the rat pancreas
    Hannibal, J
    Fahrenkrug, J
    CELL AND TISSUE RESEARCH, 2000, 299 (01) : 59 - 70
  • [23] Expression and Regulation of Pituitary Adenylate Cyclase-Activating Polypeptide in Rat Placental Cells
    Oride, Aki
    Kanasaki, Haruhiko
    Mijiddorj, Tselmeg
    Sukhbaatar, Unurjargal
    Yamada, Takaya
    Kyo, Satoru
    REPRODUCTIVE SCIENCES, 2016, 23 (08) : 1080 - 1086
  • [24] Pituitary adenylate cyclase-activating polypeptide in intrinsic and extrinsic nerves of the rat pancreas
    Jens Hannibal
    Jan Fahrenkrug
    Cell and Tissue Research, 2000, 299 (1) : 59 - 70
  • [25] Expression and Regulation of Pituitary Adenylate Cyclase-Activating Polypeptide in Rat Placental Cells
    Aki Oride
    Haruhiko Kanasaki
    Tselmeg Mijiddorj
    Unurjargal Sukhbaatar
    Takaya Yamada
    Satoru Kyo
    Reproductive Sciences, 2016, 23 : 1080 - 1086
  • [26] Effect of pituitary adenylate cyclase-activating polypeptide on GH gene expression in rat pituitary cells
    Shuto, Y
    SomogyvariVigh, A
    Vigh, S
    Wakabayashi, I
    Arimura, A
    VIP, PACAP, AND RELATED PEPTIDES, 2ND INTERNATIONAL SYMPOSIUM, 1996, 805 : 684 - 691
  • [27] STRUCTURE AND ACTIVITY OF FROG PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE
    CONLON, JM
    CHARTREL, N
    TONON, MC
    VAUDRY, H
    AMERICAN ZOOLOGIST, 1991, 31 (05): : A132 - A132
  • [28] Pituitary adenylate cyclase-activating peptide inhibits neutrophil chemotaxis
    Kinhult, J
    Uddman, R
    Laan, M
    Lindén, A
    Cardell, LO
    PEPTIDES, 2001, 22 (12) : 2151 - 2154
  • [29] The neuropeptide cyclase-activating pituitary adenylate polypeptide and islet function
    Filipsson, K
    Kvist-Reimer, M
    Ahrén, B
    DIABETES, 2001, 50 (09) : 1959 - 1969
  • [30] PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE - A KEY PLAYER IN REPRODUCTION
    MCARDLE, CA
    ENDOCRINOLOGY, 1994, 135 (03) : 815 - 817
12345