Pituitary adenylate cyclase-activating polypeptide induces hyperthermia in the rat

被引：23
|
作者：
Pataki, I [1 ]
Adamik, A [1 ]
Jászberényi, M [1 ]
Mácsai, M [1 ]
Telegdy, G [1 ]
机构：
[1] Albert Szent Gyorgyi Med Univ, Dept Pathophysiol, MTA, SZOTE Beurohumoral Res Grp, H-6701 Szeged, Hungary
来源：
NEUROPHARMACOLOGY | 2000年 / 39卷 / 07期
基金：
匈牙利科学研究基金会;
关键词：
hyperthermia; PACAP; rat; noraminophenazone;
D O I：
10.1016/S0028-3908(99)00209-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of centrally administered pituitary adenylate cyclase-activating polypeptide (PACAP-38) on body temperature were investigated in rats. Intracerebroventricular (i.c.v.) administration of PACAP-38 in doses of 500 and 1000 ng induced a dose-related elevation in colon temperature 2, 3, 4, 5 and 6 h after injection. The i.c.v. pretreatment of the animals with different dilutions of PACAP-38 antiserum prevented the development of hyperthermia in PACAP-38-treated animals, whereas PACAP-38 antiserum alone did not modify the colon temperature. An intramuscular injection of noraminophenazone (a cyclooxygenase inhibitor) abolished the PACAP-38-induced hyperthermia. Our data indicate that PACAP may induce hyperthermia via the central nervous system, and this hyperthermic effect may be mediated via a cyclooxygenase-involved pathway. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1303 / 1308
页数：6
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