ASYMMETRIC DISTRIBUTION OF ONCOGENE PRODUCTS AT MITOSIS

被引：14
|
作者：
CZERNIAK, B [1 ]
HERZ, F [1 ]
WERSTO, RP [1 ]
KOSS, LG [1 ]
机构：
[1] ALBERT EINSTEIN COLL MED,MONTEFIORE MED CTR,DEPT PATHOL,BRONX,NY 10467
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 11期
关键词：
POSTMITOTIC HETEROGENEITY; DAUGHTER CELLS; FLOW CYTOMETRY; IMAGE ANALYSIS;
D O I：
10.1073/pnas.89.11.4860
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Computer-assisted image analysis was used to demonstrate in exponentially proliferating human tumor cells the uneven postmitotic apportionment of several oncogene-encoded proteins (ras p21; erbB-2 p185; fos p55; myc p62). This observation may provide the explanation for the high degree of heterogeneity of postmitotic cells and the asynchrony in cell cycle traverse of cultured cells.
引用
收藏
页码：4860 / 4863
页数：4
相关论文
共 50 条
  • [41] DISTRIBUTION OF SISTER CHROMATIDS AT MITOSIS IN CHINESE HAMSTER CELLS
    COMINGS, DE
    CHROMOSOMA, 1970, 29 (04) : 428 - &
  • [42] Chance and checkpoint: accurate chromosome distribution in mitosis and meiosis
    Nicklas, RB
    CYTOGENETICS AND CELL GENETICS, 1998, 81 (02): : 100 - 100
  • [43] DISTRIBUTION OF RIBONUCLEIC ACID IN TUMOUR CELLS DURING MITOSIS
    LOVE, R
    NATURE, 1957, 180 (4598) : 1238 - 1239
  • [44] Distribution of Kinetochore Fragments During Mitosis with Unreplicated Genomes
    Johnson, Mary Kathrine
    Wise, Dwayne A.
    CYTOSKELETON, 2010, 67 (03) : 172 - 177
  • [45] Optimal tolerance design for products with non-normal distribution based on asymmetric quadratic quality loss
    Jin, Qiu
    Liu, Shaogang
    Wang, Ping
    INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY, 2015, 78 (1-4): : 667 - 675
  • [46] Optimal tolerance design for products with non-normal distribution based on asymmetric quadratic quality loss
    Qiu Jin
    Shaogang Liu
    Ping Wang
    The International Journal of Advanced Manufacturing Technology, 2015, 78 : 667 - 675
  • [47] MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products
    Chan, Ka Iong
    Zhang, Siyuan
    Li, Guodong
    Xu, Yida
    Cui, Liao
    Wang, Yitao
    Su, Huanxing
    Tan, Wen
    Zhong, Zhangfeng
    AGING AND DISEASE, 2024, 15 (02): : 640 - 697
  • [48] A COMPARISON OF SMOKERS AND NONSMOKERS WITH RESPECT TO ONCOGENE PRODUCTS AND CYTOGENETIC PARAMETERS
    BRINKWORTH, MH
    YARDLEYJONES, A
    EDWARDS, AJ
    HUGHES, JA
    ANDERSON, D
    JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1992, 34 (12) : 1181 - 1188
  • [49] DIFFERENTIAL EXPRESSION OF RAS ONCOGENE PRODUCTS IN LIVER-DISEASES
    LEE, I
    GOULD, KA
    SCHLOM, J
    BANNER, BF
    GOULD, VE
    LABORATORY INVESTIGATION, 1987, 56 (01) : A42 - A42
  • [50] STUDY OF THE SUITABILITY OF THE IMMUNOLOGICAL APPROACH TO DETECT NEW ONCOGENE PRODUCTS
    COLZANI, E
    PUPA, SM
    BAZZINI, P
    CENTIS, F
    MENARD, S
    TAGLIABUE, E
    COLNAGHI, MI
    JOURNAL OF IMMUNOLOGICAL RESEARCH, 1992, 4 (02): : 73 - 78
12345