ASYMMETRIC DISTRIBUTION OF ONCOGENE PRODUCTS AT MITOSIS

被引：14
|
作者：
CZERNIAK, B [1 ]
HERZ, F [1 ]
WERSTO, RP [1 ]
KOSS, LG [1 ]
机构：
[1] ALBERT EINSTEIN COLL MED,MONTEFIORE MED CTR,DEPT PATHOL,BRONX,NY 10467
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 11期
关键词：
POSTMITOTIC HETEROGENEITY; DAUGHTER CELLS; FLOW CYTOMETRY; IMAGE ANALYSIS;
D O I：
10.1073/pnas.89.11.4860
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Computer-assisted image analysis was used to demonstrate in exponentially proliferating human tumor cells the uneven postmitotic apportionment of several oncogene-encoded proteins (ras p21; erbB-2 p185; fos p55; myc p62). This observation may provide the explanation for the high degree of heterogeneity of postmitotic cells and the asynchrony in cell cycle traverse of cultured cells.
引用
收藏
页码：4860 / 4863
页数：4
相关论文
共 50 条
  • [21] CHARGE CONFIGURATIONS IN ONCOGENE PRODUCTS AND TRANSFORMING PROTEINS
    KARLIN, S
    BRENDEL, V
    ONCOGENE, 1990, 5 (01) : 85 - 95
  • [22] ONCOGENE PRODUCTS AND EXPERIMENTAL COLON CANCER IN RATS
    YANAIHARA, C
    HIROTANI, Y
    KUROKAWA, N
    IGUCHI, K
    MOCHIZUKI, T
    YANAIHARA, N
    KISHIMOTO, S
    REGULATORY PEPTIDES, 1992, 40 (02) : 283 - 283
  • [23] Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila
    Shen, CP
    Jan, LY
    Jan, YN
    CELL, 1997, 90 (03) : 449 - 458
  • [24] Asymmetric mitosis contributes to different migratory performance in sister cells
    Tamborindeguy, Mauricio Tavares
    Lorenzatto, Paola Farias
    Lamers, Marcelo Lazzaron
    Lenz, Guido
    EXPERIMENTAL CELL RESEARCH, 2023, 430 (01)
  • [25] SPATIAL-DISTRIBUTION OF MITOSIS IN MOUSE EPIDERMIS
    MACKENZIE, IC
    ANATOMICAL RECORD, 1975, 181 (04): : 705 - 710
  • [26] Asymmetrical Distribution of the Transcriptionally Competent NORs in Mitosis
    Smirnov, E.
    Popov, A.
    Masata, M.
    Kalmarova, M.
    Raska, I.
    MOLECULAR BIOLOGY OF THE CELL, 2006, 17
  • [27] Asymmetrical distribution of the transcriptionally competent NORs in mitosis
    Kalmarova, Marketa
    Kovacik, Lubomir
    Popov, Alexey
    Testillano, Sanchez Pilar
    Smirnov, Evgeny
    JOURNAL OF STRUCTURAL BIOLOGY, 2008, 163 (01) : 40 - 44
  • [28] FLOW CYTOMETRIC DETECTION OF DNA TUMOR-VIRUS NUCLEAR ONCOGENE PRODUCTS IN UNFIXED CELLS - SAPONIN FACS OF VIRAL ONCOGENE PRODUCTS
    EYLER, YL
    LANTZ, LM
    LEWIS, AM
    JOURNAL OF VIROLOGICAL METHODS, 1994, 46 (01) : 23 - 27
  • [29] Growth factors and oncogene products in transitional cell carcinoma
    Nakanishi, K
    Kawai, T
    Suzuki, M
    Torikata, C
    MODERN PATHOLOGY, 1996, 9 (03) : 292 - 297
  • [30] Oncogene products represent potential targets of tumor vaccines
    Tuttle, TM
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 1996, 43 (03) : 135 - 141
12345