ASYMMETRIC DISTRIBUTION OF ONCOGENE PRODUCTS AT MITOSIS

被引：14

作者：

CZERNIAK, B ^{[1
]}

HERZ, F ^{[1
]}

WERSTO, RP ^{[1
]}

KOSS, LG ^{[1
]}

机构：

[1] ALBERT EINSTEIN COLL MED,MONTEFIORE MED CTR,DEPT PATHOL,BRONX,NY 10467

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 11期

关键词：

POSTMITOTIC HETEROGENEITY; DAUGHTER CELLS; FLOW CYTOMETRY; IMAGE ANALYSIS;

D O I：

10.1073/pnas.89.11.4860

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Computer-assisted image analysis was used to demonstrate in exponentially proliferating human tumor cells the uneven postmitotic apportionment of several oncogene-encoded proteins (ras p21; erbB-2 p185; fos p55; myc p62). This observation may provide the explanation for the high degree of heterogeneity of postmitotic cells and the asynchrony in cell cycle traverse of cultured cells.

引用

页码：4860 / 4863

页数：4

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