ASYMMETRIC DISTRIBUTION OF ONCOGENE PRODUCTS AT MITOSIS

被引：14
|
作者：
CZERNIAK, B [1 ]
HERZ, F [1 ]
WERSTO, RP [1 ]
KOSS, LG [1 ]
机构：
[1] ALBERT EINSTEIN COLL MED,MONTEFIORE MED CTR,DEPT PATHOL,BRONX,NY 10467
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 11期
关键词：
POSTMITOTIC HETEROGENEITY; DAUGHTER CELLS; FLOW CYTOMETRY; IMAGE ANALYSIS;
D O I：
10.1073/pnas.89.11.4860
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Computer-assisted image analysis was used to demonstrate in exponentially proliferating human tumor cells the uneven postmitotic apportionment of several oncogene-encoded proteins (ras p21; erbB-2 p185; fos p55; myc p62). This observation may provide the explanation for the high degree of heterogeneity of postmitotic cells and the asynchrony in cell cycle traverse of cultured cells.
引用
收藏
页码：4860 / 4863
页数：4
相关论文
共 50 条
12345