SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF 5-AMIDOBENZOTRIAZOLE DERIVATIVES

被引：4
|
作者：
CALIENDO, G
NOVELLINO, E
SAGLIOCCO, G
SANTAGADA, V
SILIPO, C
VITTORIA, A
机构：
[1] NAPLES UNIV,DEPARTIMENTO CHIM FARMACEUT & TOSSICOL,VIA D MONTESANO 49,I-80131 NAPLES,ITALY
[2] FAC MED & CHIRURG NAPLES,IST IGIENE & MED PREVENT,I-80131 NAPLES,ITALY
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 04期
关键词：
antimicrobial activity; benzotriazoles; lipophilicity;
D O I：
10.1016/0223-5234(90)90118-M
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 2-cyclopentyl-5-amidobenzotriazole derivatives has been prepared and characterized. Shake-flask partition coefficients (log P) and capacity factors (log k1) were experimentally determined and correlated through regression analysis. The in vitro antimicrobial activity of prepared compounds against gram-positive, gram-negative bacteria and Candida albicans are discussed in function of their structural features. Some derivatives are characterized by interesting antimicrobial activities. © 1990.
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收藏
页码：343 / 350
页数：8
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