SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF 5-AMIDOBENZOTRIAZOLE DERIVATIVES

被引：4
|
作者：
CALIENDO, G
NOVELLINO, E
SAGLIOCCO, G
SANTAGADA, V
SILIPO, C
VITTORIA, A
机构：
[1] NAPLES UNIV,DEPARTIMENTO CHIM FARMACEUT & TOSSICOL,VIA D MONTESANO 49,I-80131 NAPLES,ITALY
[2] FAC MED & CHIRURG NAPLES,IST IGIENE & MED PREVENT,I-80131 NAPLES,ITALY
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 04期
关键词：
antimicrobial activity; benzotriazoles; lipophilicity;
D O I：
10.1016/0223-5234(90)90118-M
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 2-cyclopentyl-5-amidobenzotriazole derivatives has been prepared and characterized. Shake-flask partition coefficients (log P) and capacity factors (log k1) were experimentally determined and correlated through regression analysis. The in vitro antimicrobial activity of prepared compounds against gram-positive, gram-negative bacteria and Candida albicans are discussed in function of their structural features. Some derivatives are characterized by interesting antimicrobial activities. © 1990.
引用
收藏
页码：343 / 350
页数：8
相关论文
共 50 条
  • [41] Synthesis and Antimicrobial Activities of Boron-Containing Isoniazid Derivatives
    Thomas I. Kostelnik
    Morgan K. Morrissey
    Christopher M. Vogels
    Jason D. Masuda
    Stephen A. Westcott
    Chemistry Africa, 2023, 6 : 1209 - 1216
  • [42] A CONVENIENT SYNTHESIS OF NOVEL COUMARIN DERIVATIVES WITH ANTICIPATED ANTIMICROBIAL ACTIVITIES
    Mourad, Asmaa Kamal
    Essawy, Abd El-Naby Ibrahim
    Younus, Hussein Abdel-Azim
    HETEROCYCLES, 2017, 94 (11) : 2039 - 2053
  • [43] Synthesis of Some Novel Triazole Derivatives and Investigation of Their Antimicrobial Activities
    Altintop, Mehlika Dilek
    Kaplancikli, Zafer Asim
    Turan-Zitouni, Gulhan
    Ozdemir, Ahmet
    Demirci, Fatih
    Iscan, Gokalp
    Revial, Gilbert
    SYNTHETIC COMMUNICATIONS, 2011, 41 (15) : 2234 - 2250
  • [44] Mini review on synthesis, antimicrobial and cytotoxic activities of oxazinone derivatives
    Asif, Mohammad
    MOROCCAN JOURNAL OF CHEMISTRY, 2015, 3 (03): : 423 - 431
  • [45] Synthesis, characterization and antimicrobial activities of amide derivatives of febuxostat intermediate
    Badvel, Sreedhar
    Tummaluru, Veera Reddy
    Katta, Venugopal Reddy
    Gandi, Vidya Sagar Reddy
    Chamarthi, Naga Raju
    Venkatapuram, Padmavathi
    ORGANIC COMMUNICATIONS, 2015, 8 (02) : 43 - 51
  • [46] Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities
    Monte, Zenaide S.
    Silva, Amanda M.
    Lima, Glaucia M. S.
    da Silva, Teresinha G.
    Marques, Karla M. R.
    Rodrigues, Maria D.
    Falcao, Emerson P. S.
    Melo, Sebastiao J.
    ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2017, 89 (02): : 1051 - 1058
  • [47] SYNTHESIS, ANTIMICROBIAL AND ANTIVIRAL ACTIVITIES OF ISOTRIMETHOPRIM AND SOME RELATED DERIVATIVES
    BOTTA, M
    ARTICO, M
    MASSA, S
    GAMBACORTA, A
    MARONGIU, ME
    PANI, A
    LACOLLA, P
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (03) : 251 - 257
  • [48] Synthesis of new thiazole derivatives and evaluation of their antimicrobial and cytotoxic activities
    Dawbaa, Sam
    Evren, Asaf Evrim
    Canturk, Zerrin
    Yurttas, Leyla
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2021, 196 (12) : 1093 - 1102
  • [49] Synthesis, Reactions and Antimicrobial Activities of 8-Ethoxycoumarin Derivatives
    Mohamed, Hany M.
    Abd El-Wahab, Ashraf H. F.
    Ahmed, Kamal A.
    El-Agrody, Ahmed M.
    Bedair, Ahmed H.
    Eid, Fathy A.
    Khafagy, Mostafa M.
    MOLECULES, 2012, 17 (01): : 971 - 988
  • [50] New Approaches for the Synthesis of Thiazoles and Their Fused Derivatives with Antimicrobial Activities
    Wardkhan, Wagnat W.
    Youssef, Mohamed A.
    Hamed, Faten I.
    Ouf, Salama A.
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2008, 55 (05) : 1133 - 1144
12345