METHOTREXATE FOR SYSTEMIC LUPUS-ERYTHEMATOSUS - A RETROSPECTIVE ANALYSIS OF 17 UNSELECTED CASES

被引：0

作者：

WILKE, WS ^{[1
]}

KRALL, PL ^{[1
]}

SCHEETZ, RJ ^{[1
]}

BABIAK, T ^{[1
]}

DANAO, T ^{[1
]}

MAZANEC, DJ ^{[1
]}

SEGAL, AM ^{[1
]}

CLOUGH, JD ^{[1
]}

机构：

[1] CLEVELAND CLIN FDN,DEPT RHEUMAT & IMMUNOL DIS,CLEVELAND,OH 44195

来源：

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 1991年 / 9卷 / 06期

关键词：

METHOTREXATE; SYSTEMIC LUPUS ERYTHEMATOSUS; THERAPY; METHOTREXATE TOXICITY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a retrospective study of 17 patients with systemic lupus erythematosus who were treated with oral methotrexate given as a mean weekly dose of 8.47 +/- 1.72 mg. Methotrexate treatment resulted in symptomatic improvement in 57% of patients and allowed the reduction of the mean daily dose of prednisone from 16.66 mg initially to 8.99 mg at one year follow-up. Twelve of 17 patients (70.6%) experienced at least one episode of toxicity. Factors which might be associated with toxicity are analyzed. Because of its potential as a corticosteroid-sparing agent, controlled studies of methotrexate for the treatment of systemic lupus erythematosus are indicated.

引用

页码：581 / 587

页数：7

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